Biohybrid Microalgae Robots: Design, Fabrication, Materials, and Applications

The integration of microorganisms and engineered artificial components has shown considerable promise for creating biohybrid microrobots. The unique features of microalgae make them attractive candidates as natural actuation materials for the design of biohybrid microrobotic systems. In this review, microalgae-based biohybrid microrobots are introduced for diverse biomedical and environmental applications. The distinct propulsion and phototaxis behaviors of green microalgae, as well as important properties from other photosynthetic microalga systems (blue-green algae and diatom) that are crucial to constructing powerful biohybrid microrobots, will be described first. Then the focus is on chemical and physical routes for functionalizing the algae surface with diverse reactive materials toward the fabrication of advanced biohybrid microalgae robots. Finally, representative applications of such algae-driven microrobots are presented, including drug delivery, imaging, and water decontamination, highlighting the distinct advantages of these active biohybrid robots, along with future prospects and challenges. Powered by flagella beating, functionalized microalgae robots are demonstrated to move through various biological fluids, water matrices and harsh environments, while performing diverse tasks toward critical biomedical and environmental applications. This review introduces the design, preparation, fabrication, unique functions and latest progress and applications of microalgae-based biohybrid microrobots, leveraging the attractive self-propulsion capability of natural microalgae and the versatile modalities of functional materials.image