Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers

被引:4
|
作者
Xiong, Hongtai [1 ]
Han, Xinpu [1 ]
Cai, Liu [2 ]
Zheng, Honggang [1 ]
机构
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, Beijing, Peoples R China
[2] Shaanxi Univ Chinese Med, Clin Med Coll 1, Xianyang, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
基金
中国国家自然科学基金;
关键词
natural polysaccharide; dendritic cell; anti-tumor mechanism; immune function; DC vaccine; nanoparticle; INDUCED KILLER-CELLS; ASTRAGALUS POLYSACCHARIDE; HEPATOCELLULAR-CARCINOMA; CANCER-IMMUNOTHERAPY; CROSS-PRESENTATION; IN-VITRO; NANOPARTICLE; MATURATION; ANTIGEN; VACCINE;
D O I
10.3389/fonc.2023.1274048
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
With the development of immunotherapy, the process of tumor treatment is also moving forward. Polysaccharides are biological response modifiers widely found in plants, animals, fungi, and algae and are mainly composed of monosaccharides covalently linked by glycosidic bonds. For a long time, polysaccharides have been widely used clinically to enhance the body's immunity. However, their mechanisms of action in tumor immunotherapy have not been thoroughly explored. Dendritic cells (DCs) are a heterogeneous population of antigen presenting cells (APCs) that play a crucial role in the regulation and maintenance of the immune response. There is growing evidence that polysaccharides can enhance the essential functions of DCs to intervene the immune response. This paper describes the research progress on the anti-tumor immune effects of natural polysaccharides on DCs. These studies show that polysaccharides can act on pattern recognition receptors (PRRs) on the surface of DCs and activate phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappa B), Dectin-1/Syk, and other signalling pathways, thereby promoting the main functions of DCs such as maturation, metabolism, antigen uptake and presentation, and activation of T cells, and then play an anti-tumor role. In addition, the application of polysaccharides as adjuvants for DC vaccines, in combination with adoptive immunotherapy and immune checkpoint inhibitors (ICIs), as well as their co-assembly with nanoparticles (NPs) into nano drug delivery systems is also introduced. These results reveal the biological effects of polysaccharides, provide a new perspective for the anti-tumor immunopharmacological research of natural polysaccharides, and provide helpful information for guiding polysaccharides as complementary medicines in cancer immunotherapy.
引用
收藏
页数:18
相关论文
共 50 条
  • [21] Potentiation of anti-tumor immune effects by PARP Inhibitors
    Chabanon, R.
    Muirhead, G.
    Krastev, D.
    Adam, J.
    Garrido, M.
    Morel, D.
    Dorvault, N.
    Pettitt, S.
    Tutt, A. N. J.
    Marabelle, A.
    Soria, J. C.
    Lord, C. J.
    Postel-Vinay, S.
    RADIOTHERAPY AND ONCOLOGY, 2020, 152 : S132 - S132
  • [22] Tumor-altered dendritic cell function: implications for anti-tumor immunity
    Hargadon, Kristian M.
    FRONTIERS IN IMMUNOLOGY, 2013, 4
  • [23] Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis
    Peng Shang Wen-Ming Zhao School of Life Science and Technology
    World Journal of Gastroenterology, 2003, 9 (09) : 1963 - 1967
  • [24] Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis
    Shang, P
    Qian, AR
    Yang, TH
    Jia, M
    Mei, QB
    Cho, CH
    Zhao, WM
    Chen, ZN
    WORLD JOURNAL OF GASTROENTEROLOGY, 2003, 9 (09) : 1963 - 1967
  • [25] Immunoregulatory and Anti-Tumor Effects of Polysaccharopeptide and Astragalus polysaccharides on Tumor-Bearing Mice
    Li Jin
    Bao Yixi
    Lam Waikei
    Li Wenwen
    Lu Fang
    Zhu Xuan
    Liu Jing
    Wang Hongping
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2008, 30 (04) : 771 - 782
  • [26] Polysaccharides as Potential Anti-tumor Biomacromolecules -A Review
    Guo, Rui
    Chen, Min
    Ding, Yangyang
    Yang, Pengyao
    Wang, Mengjiao
    Zhang, Haihui
    He, Yuanqing
    Ma, Haile
    FRONTIERS IN NUTRITION, 2022, 9
  • [27] Chemical modifications of polysaccharides and their anti-tumor activities
    Xie, Liuming
    Shen, Mingyue
    Hong, Yuzhen
    Ye, Hedan
    Huang, Lixin
    Xie, Jianhua
    CARBOHYDRATE POLYMERS, 2020, 229
  • [28] Alcohol exposure differentially effects anti-tumor immunity in females by altering dendritic cell function
    Thompson, Matthew G.
    Navarro, Flor
    Chitsike, Lennox
    Ramirez, Luis
    Kovacs, Elizabeth J.
    Watkins, Stephanie K.
    ALCOHOL, 2016, 57 : 1 - 8
  • [29] Superior anti-tumor immune response of dendritic cells fused with prostate cancer cell lines compared with tumor lysate-pulsed dendritic cells
    Lee, SB
    Lee, JM
    Jun, SY
    Yoo, C
    Song, SH
    JOURNAL OF UROLOGY, 2006, 175 (04): : 143 - 143
  • [30] Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma
    Bustamante, Prisca
    Miyamoto, Denise
    Goyeneche, Alicia
    Graue, Paulina Garcia de Alba
    Jin, Eva
    Tsering, Thupten
    Dias, Ana Beatriz
    Burnier, Miguel N.
    Burnier, Julia, V
    CANCER MEDICINE, 2019, 8 (17): : 7265 - 7277