Nanoparticles Bind to Endothelial Cells in Injured Blood Vessels via a Transient Protein Corona

被引：12

作者：

Lin, Zachary P. ^{[1
,2
]}

Ngo, Wayne ^{[1
,2
]}

Mladjenovic, Stefan M. ^{[1
,2
]}

Wu, Jamie L. Y. ^{[1
,2
]}

Chan, Warren C. W. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Toronto, Inst Biomed Engn, Toronto, ON M5S 3G9, Canada

[2] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5 3E1, Canada

[3] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada

[4] Univ Toronto, Dept Mat Sci & Engn, Toronto, ON M5S 1A1, Canada

[5] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

NANO LETTERS | 2023年 / 23卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Nanoparticles; Protein Corona; Platelet factor 4; Vessels; Endothelial cells; Delivery; LOW-DENSITY-LIPOPROTEIN; CHEMOKINE PLATELET-FACTOR-4; MODELS;

D O I：

10.1021/acs.nanolett.2c04501

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoparticles travel through blood vessels to reach disease sites, but the local environment they encounter may affect their surface chemistry and cellular interactions. Here, we found that as nanoparticles transit through injured blood vessels they may interact with a highly localized concentration of platelet factor 4 proteins released from activated platelets. The platelet factor 4 binds to the nanoparticle surface and interacts with heparan sulfate proteoglycans on endothelial cells, and induces uptake. Understanding nanoparticle interactions with blood proteins and endothelial cells during circulation is critical to optimizing their design for diseased tissue targeting and delivery.

引用

页码：1003 / 1009

页数：7

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