Preparation of cellulose-PVA blended hydrogels for wound healing applications with controlled release of the antibacterial drug: an in vitro anticancer activity

Recently, extensive research works are going on hydrogel-based wound healing and drug release materials. In the present research work, PVA/cellulose hydrogel (PCH) membrane was prepared to assess its drug release activity against pathogens or microorganisms and cancer-causing Jurkat cells. The structure of the PVA/cellulose hydrogel was confirmed by FTIR and XRD. The morphology of the PCH membrane was assessed by SEM. The thermal stability of the PCH membrane was assessed by TGA. The -OH stretching appeared at 3366 cm(-1) in the FTIR spectrum. The XRD confirmed the amorphous nature of the PVA/cellulose hydrogel membrane. The percentage residue that remained above 600 degrees C was higher for PCH membrane as compared with PVA. The wound dressing characteristics of the prepared PCH membrane were evaluated by performing various analyses such as swelling index, degradation, hemocompatibility, blood clot, and antibacterial drug delivery activity. The PCH membrane also showed a high water-absorbing potential. The hemocompatibility analysis proved that there was no marked level of hemolysis. The PCH membrane effectively inhibited the growth of pathogens or microorganisms and cancer-causing Jurkat cells by delivering the drugs at a controlled rate. In the present research work, the anticancer and antimicrobial properties of the PCH membrane were extensively studied. The drug release study of PVA/cellulose hydrogel was performed to analyze the drug release model and mechanism. The PCH membrane satisfied the important characteristics of ideal wound dressing materials.