Investigating the Relationship between Home Parenteral Support and Needs-Based Quality of Life in Patients with Chronic Intestinal Failure: A National Multi-Centre Longitudinal Cohort Study

被引：5

作者：

Jones, Debra ^{[1
]}

Lal, Simon ^{[2
]}

French, Chloe ^{[1
]}

Sowerbutts, Anne Marie ^{[1
]}

Gittins, Matthew ^{[1
]}

Gabe, Simon ^{[3
]}

Brundrett, Diane ^{[3
]}

Culkin, Alison ^{[3
]}

Calvert, Chris ^{[4
]}

Thompson, Beth ^{[4
]}

Cooper, Sheldon C. ^{[5
]}

Fletcher, Jane ^{[5
]}

Donnellan, Clare ^{[6
]}

Forbes, Alastair ^{[7
,8
]}

Lam, Ching ^{[9
]}

Radford, Shellie ^{[10
]}

Mountford, Christopher G. ^{[11
]}

Rogers, Daniel ^{[12
]}

Muggridge, Rebecca ^{[12
]}

Sharkey, Lisa ^{[13
]}

Neild, Penny ^{[14
]}

Wheatley, Carolyn ^{[15
]}

Stevens, Philip ^{[16
]}

Burden, Sorrel ^{[1
,2
]}

机构：

[1] Univ Manchester, Sch Hlth Sci, Div Nursing Midwifery & Social Work, Manchester M13 9PL, England

[2] Salford Royal Fdn Trust, Intestinal Failure Unit, Salford M6 8HD, England

[3] London North West Univ Healthcare NHS Trust, St Marks Hosp, London HA1 3UJ, England

[4] Royal Devon & Exeter NHS Fdn Trust, Intestinal Failure & Nutr Team, Exeter EX2 5DW, England

[5] Univ Hosp Birmingham NHS Fdn Trust, GI Med, Birmingham B15 2TH, England

[6] Leeds Teaching Hosp NHS Trust, Leeds Gastroenterol Inst, Leeds LS9 7JT, England

[7] Univ East Anglia, Norwich Med Sch, Norwich NR4 7UQ, England

[8] Univ Tartu, Inst Clin Med, EE-50090 Tartu, Estonia

[9] Northern Gen Hosp, Sheffield Teaching Hosp NHS Fdn Trust, Sheffield S5 7AU, England

[10] Nottingham Univ Hosp NHS Trust, Queens Med Ctr Campus, Nottingham NG7 2UH, England

[11] Newcastle Tyne Hosp NHS Fdn Trust, Newcastle NE1 4LP, England

[12] Univ Hosp Leicester NHS Trust, Leicester Royal Infirm, Leicester Intestinal Failure Team, Leicester LE1 5WW, England

[13] Cambridge Univ Hosp NHS Fdn Trust, Gastroenterol, Cambridge CB2 0QQ, England

[14] St Georges Univ Hosp NHS Fdn Trust, Dept Gastroenterol, London SW17 0QT, England

[15] Patients Intravenous & Naso Gastr Nutr Treatment, Christchurch BH23 2XS, Dorset, England

[16] Glasgow Royal Infirm, Glasgow G4 0SF, Scotland

来源：

NUTRIENTS | 2023年 / 15卷 / 03期

关键词：

home parenteral nutrition; home parenteral support; quality of life; patient-reported outcomes; longitudinal study; parenteral nutrition impact questionnaire (PNIQ); NUTRITION DEPENDENCE; ADULT PATIENTS; SURVIVAL; MANAGEMENT; IMPACT; SF-36; VALIDATION; ARTICLE;

D O I：

10.3390/nu15030622

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Home parenteral support (HPS) is an essential but potentially burdensome treatment that can affect quality of life (QoL). The aims of this longitudinal study were to understand whether any changes in HPS over time were associated with QoL. The Parenteral Nutrition Impact Questionnaire (PNIQ) was used, and data were collected on HPS prescribed at three time points. Data were analysed using multi-level mixed regression models presented as effect size and were adjusted for confounders. Study recruited 572 participants from 15 sites. Of these, 201 and 145 completed surveys at second and third time-points, respectively. PNIQ score was out of 20 with a higher score indicating poorer QoL. Any reduction in HPS infusions per week was associated with an improved PNIQ score of -1.10 (95% CI -2.17, -0.02) unadjusted and -1.34 (95% CI -2.45, -0.24) adjusted. Per day change to the number of infusions per week was associated with a change in the PNIQ score of 0.32 (95% CI -0.15, 0.80) unadjusted and 0.34 (95% CI -0.17, 0.85) adjusted. This is the largest national study to demonstrate improvements in QoL associated with HPS reduction over time using an HPS-specific and patient-centric tool, adding unique data for use of therapies in intestinal failure.

引用

页数：12

共 38 条

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