Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study

被引：6

作者：

Stoliaroff-Pepin, Anna ^{[1
]}

Peine, Caroline ^{[1
]}

Herath, Tim ^{[1
]}

Lachmann, Johannes ^{[1
]}

Hellenbrand, Wiebke ^{[1
]}

Perriat, Delphine ^{[1
]}

Doerre, Achim ^{[2
]}

Nitsche, Andreas ^{[3
,4
]}

Michel, Janine ^{[3
,4
]}

Grossegesse, Marica ^{[3
,4
]}

Hofmann, Natalie ^{[3
,4
]}

Rinner, Thomas ^{[3
,4
]}

Kohl, Claudia ^{[3
,4
]}

Brinkmann, Annika ^{[3
,4
]}

Meyer, Tanja ^{[5
]}

Stern, Daniel ^{[5
]}

Treindl, Fridolin ^{[5
]}

Dorner, Brigitte G. ^{[5
]}

Hein, Sascha ^{[6
]}

Werel, Laura ^{[6
]}

Hildt, Eberhard ^{[6
]}

Glaeser, Sven ^{[7
]}

Schuehlen, Helmut ^{[8
]}

Isner, Caroline ^{[9
]}

Peric, Alexander ^{[10
]}

Ghouzi, Ammar ^{[11
]}

Reichardt, Annette ^{[12
]}

Janneck, Matthias ^{[13
]}

Lock, Guntram ^{[14
]}

Huster, Dominik ^{[15
]}

Gruenewald, Thomas ^{[16
]}

Schaade, Lars ^{[17
]}

Wichmann, Ole ^{[1
]}

Harder, Thomas ^{[1
]}

机构：

[1] Robert Koch Inst, Dept Infect Dis Epidemiol, Immunizat Unit, Berlin, Germany

[2] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany

[3] Robert Koch Inst, Ctr Biol Threats & Special Pathogens, WHO Reference Lab SARS CoV 2, ZBS1 Highly Pathogen Viruses, Berlin, Germany

[4] Robert Koch Inst, WHO Collaborating Ctr Emerging Infect & Biol Thre, ZBS1 Highly Pathogen Viruses, Berlin, Germany

[5] Robert Koch Inst, Ctr Biol Threats & Special Pathogens, ZBS3 Biol Toxins, Berlin, Germany

[6] Paul Ehrlich Inst, Div Virol, Paul Ehrlich Str 51-59, D-63225 Langen, Germany

[7] Vivantes Klinikum Neukolln & Spandau, Klin Innere Med Pneumol & Infektiol, Berlin, Germany

[8] Vivantes Netzwerk Gesundheit GmbH, Direktorat Klin Forsch & Akad Lehre, Berlin, Germany

[9] Vivantes Auguste Viktoria Klinikum, Klin Innere Med Infektiol, Rubensstr 125, D-12157 Berlin, Germany

[10] Vivantes Klinikum Friedrichshain, Klin Pneumol & Infektiol, Landsberger Allee 49, D-10249 Berlin, Germany

[11] Schon Klin Dusseldorf, Interdisziplinare Notaufnahme, Heerdter Krankenhaus 2, D-40549 Dusseldorf, Germany

[12] Helios Klinikum Berlin Buch, Schwanebecker Chaussee 50, D-13125 Berlin, Germany

[13] Albertinen Krankenhaus, Klin Kardiol, Sekt Nephrol, Suntelstr 11a, D-22457 Hamburg, Germany

[14] Albertinen Krankenhaus, Klin Innere Med, Suntelstr 11a, D-22457 Hamburg, Germany

[15] Helios Klinikum Erfurt, Klin Innere Med, Erfurt, Germany

[16] Klinikum Chemnitz, Klin Infekt & Tropenmed, Chemnitz, Germany

[17] Robert Koch Inst, Ctr Biol Threats & Special Pathogens, Berlin, Germany

来源：

INFECTION | 2023年 / 51卷 / 04期

关键词：

COVID-19; Vaccine effectiveness; Hospitalization; Case-control study; SARS-CoV-2; Omicron;

D O I：

10.1007/s15010-023-02012-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

PurposeCOViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave.MethodsWe analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates.Results21% of cases (57/276) were not vaccinated, compared to 5% of controls (26/494; p < 0.001). Confounder-adjusted VE against COVID-19-caused hospitalization was 55.4% (95% CI: 12-78%), 81.5% (95% CI: 68-90%) and 95.6% (95%CI: 88-99%) after two, three and four vaccine doses, respectively. VE against hospitalization due to COVID-19 remained stable up to one year after three vaccine doses.ConclusionThree vaccine doses remained highly effective in preventing severe disease and this protection was sustained; a fourth dose further increased protection.

引用

页码：1093 / 1102

页数：10

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