Antitumor activity of novel and potent YAP/TAZ-TEAD inhibitorstargeting the Hippo pathway in solid tumors

被引:1
|
作者
Kim, Jisook
Jung, Seung Hyun
Han, Seon Yeong
Yoon, Jihee
Kim, Minjeong
Byun, Jooyun
Moon, Heesun
Lee, Eunyoung
Kim, Yu-Yon
Park, Hyunjin
Jeon, Ye
Ahn, Young Gil
Kim, Young Hoon
Suh, Kwee Hyun
机构
关键词
D O I
10.1158/1538-7445.AM2023-1614
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1614
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer
    Emami, Sahar Sarmasti
    Ge, Anni
    Zhang, Derek
    Hao, Yawei
    Ling, Min
    Rubino, Rachel
    Nicol, Christopher J. B.
    Wang, Wenqi
    Yang, Xiaolong
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (07)
  • [42] BBT-4437, a novel, brain-penetrable, reversible pan-TEAD inhibitor targeting the Hippo signaling pathway in solid tumors
    Revollo, Leila
    Brenneman, Jehrod
    Paudyal, Shared
    Nguyen, Toan
    Lee, Yong-Hee
    Jin, Taiguang Jimmy
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [43] Icariin modulates osteogenic and adipogenic differentiation in ADSCs via the Hippo-YAP/TAZ pathway: a novel therapeutic strategy for osteoporosis
    Lin, Shaozi
    Meng, Zuyu
    Wang, Mei
    Ye, Zixuan
    Long, Mengsha
    Zhang, Yiyao
    Liu, Fang
    Chen, Hongling
    Li, Menghan
    Qin, Jiajia
    Liu, Haiquan
    FRONTIERS IN PHARMACOLOGY, 2025, 15
  • [44] Hippo Pathway (HP) Activity In Acute Myelogenous Leukemia (AML): Different Prognostic Implications Of TAZ versus YAP Inactivation By Phosphorylation
    Kornblau, Steven M.
    Hu, Chenyu W.
    Qiu, Yi Hua
    Yoo, Suk Young
    Zhang, Nianxiang
    Kadia, Tapan M.
    Ferrajoli, Alessandra
    Coombes, Kevin R.
    Qutub, Amina A.
    BLOOD, 2013, 122 (21)
  • [45] A novel extrinsic apoptosis pathway regulated via the p53-p53PAD7-Hippo-YAP/TAZ axis
    Takikawa, Masahiro
    Okabe, Atsushi
    Kaneda, Atsushi
    Ishikawa, Fuyuki
    Sadaie, Mahito
    Ohki, Rieko
    CANCER SCIENCE, 2024, 115 : 1214 - 1214
  • [46] The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass
    Nishioka, Noriyuki
    Inoue, Ken-ichi
    Adachi, Kenjiro
    Kiyonari, Hiroshi
    Ota, Mitsunori
    Ralston, Amy
    Yabuta, Norikazu
    Hirahara, Shino
    Stephenson, Robert O.
    Ogonuki, Narumi
    Makita, Ryosuke
    Kurihara, Hiroki
    Morin-Kensicki, Elizabeth M.
    Nojima, Hiroshi
    Rossant, Janet
    Nakao, Kazuki
    Niwa, Hitoshi
    Sasaki, Hiroshi
    DEVELOPMENTAL CELL, 2009, 16 (03) : 398 - 410
  • [47] The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
    Sasaki, Hiroshi
    MECHANISMS OF DEVELOPMENT, 2009, 126 : S22 - S22
  • [48] YAP1-HIPPO pathway as a novel prognostic marker and therapeutic target for pediatric patients with adrenocortical tumors (ACT)
    More, Candy Bellido
    Bueno, Ana Carolina
    Castro, Margaret
    Antonini, Sonir
    HORMONE RESEARCH IN PAEDIATRICS, 2019, 91 : 60 - 60
  • [49] CEA TCB, a novel T-cell bispecific antibody with potent in vitro and in vivo antitumor activity against solid tumors
    Bacac, Marina
    Fauti, Tanja
    Colombetti, Sara
    Sam, Johannes
    Nicolini, Valeria
    Steinhoff, Nathalie
    Ast, Oliver
    Bruenker, Peter
    Hosse, Ralf
    Hofer, Thomas
    Moessner, Ekkehard
    Jaeger, Christiane
    Saro, Jose
    Karanikas, Vaios
    Klein, Christian
    Umana, Pablo
    CANCER RESEARCH, 2015, 75
  • [50] Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors
    Guilbaud, N
    Kraus-Berthier, L
    Meyer-Losic, F
    Malivet, V
    Chacun, C
    Jan, M
    Tillequin, F
    Michel, S
    Koch, M
    Pfeiffer, B
    Atassi, G
    Hickman, J
    Pierré, A
    CLINICAL CANCER RESEARCH, 2001, 7 (08) : 2573 - 2580