Targeting T cell checkpoints and myeloid suppressor cells is effective in pancreatic cancer

被引：0
|
作者：
Gulhati, Pat [1 ]
DePinho, Ronald A. [2 ]
机构：
[1] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08901 USA
[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
来源：
NATURE CANCER | 2023年 / 4卷 / 01期
关键词：
D O I：
10.1038/s43018-022-00501-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Modulation of T cell immune checkpoints combined with inhibition of chemokine receptors on myeloid-derived suppressor cells can reprogram the highly suppressive tumor immune microenvironment of pancreatic ductal adenocarcinoma (PDAC), and generates durable complete responses in a PDAC mouse model. These results provide a testable clinical regimen for human PDAC.
引用
收藏
页码：7 / 8
页数：2
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