COVID-19: Inhaled galectin-3 inhibitor safe and effective?

被引：0
|
作者：
Simon, Annika
机构：
来源：
PNEUMOLOGIE | 2023年 / 77卷 / 09期
关键词：
D O I：
10.1055/a-2038-6796
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Eine hohe Konzentration von zirkulierendem Galektin-3 wird mit schlechtem Outcome bei Betroffenen einer Coronavirus-Erkrankung (COVID-19) in Verbindung gebracht. In diesem Kontext wollten Gaughan et al. die Hypothese prufen, dass GB0139, ein potenter inhalativer Thiodigalactosid-Galektin-3-Inhibitor mit entzundungshemmender Wirkung, bei COVID-19-Pneumonitis sicher und wirksam ware, und stellen nun ihre Phase-Ib/IIa-Studie zum Thema vor.
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Galectin-3 Inhibition in COVID-19
    Reddy, Kiran
    Nichol, Alistair
    McAuley, Daniel F.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207 (02) : 118 - 120
  • [2] An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE)
    Gaughan, Erin E.
    Quinn, Tom M.
    Mills, Andrew
    Bruce, Annya M.
    Antonelli, Jean
    MacKinnon, Alison C.
    Aslanis, Vassilios
    Li, Feng
    O'Connor, Richard
    Boz, Cecilia
    Mills, Ross
    Emanuel, Philip
    Burgess, Matthew
    Rinaldi, Giulia
    Valanciute, Asta
    Mills, Bethany
    Scholefield, Emma
    Hardisty, Gareth
    Findlay, Emily Gwyer
    Parker, Richard A.
    Norrie, John
    Dear, James W.
    Akram, Ahsan R.
    Koch, Oliver
    Templeton, Kate
    Dockrell, David H.
    Walsh, Timothy S.
    Partridge, Stephen
    Humphries, Duncan
    Wang-Jairaj, Jie
    Slack, Robert J.
    Schambye, Hans
    Phung, De
    Gravelle, Lise
    Lindmark, Bertil
    Shankar-Hari, Manu
    Hirani, Nikhil
    Sethi, Tariq
    Dhaliwal, Kevin
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207 (02) : 138 - 149
  • [3] Galectin-3 as a Marker for Increased Thrombogenicity in COVID-19
    Puccini, Marianna
    Jakobs, Kai
    Reinshagen, Leander
    Friebel, Julian
    Schencke, Philipp-Alexander
    Ghanbari, Emily
    Landmesser, Ulf
    Haghikia, Arash
    Kraenkel, Nicolle
    Rauch, Ursula
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [4] Increased Levels of Galectin-3 in Critical COVID-19
    Nikitopoulou, Ioanna
    Vassiliou, Alice G.
    Athanasiou, Nikolaos
    Jahaj, Edison
    Akinosoglou, Karolina
    Dimopoulou, Ioanna
    Orfanos, Stylianos E.
    Dimakopoulou, Vasiliki
    Schinas, Georgios
    Tzouvelekis, Argyrios
    Aidinis, Vassilis
    Kotanidou, Anastasia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (21)
  • [5] Galectin-3 as an important prognostic marker for COVID-19 severity
    Nevena Gajovic
    Sofija Sekulic Markovic
    Milena Jurisevic
    Marina Jovanovic
    Nebojsa Arsenijevic
    Zeljko Mijailovic
    Marina Jovanovic
    Ivan Jovanovic
    Scientific Reports, 13
  • [6] Galectin-3 as an important prognostic marker for COVID-19 severity
    Gajovic, Nevena
    Markovic, Sofija Sekulic
    Jurisevic, Milena
    Jovanovic, Marina
    Arsenijevic, Nebojsa
    Mijailovic, Zeljko
    Jovanovic, Marina
    Jovanovic, Ivan
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [7] A potential role for Galectin-3 inhibitors in the treatment of COVID-19
    Caniglia, John L.
    Guda, Maheedhara R.
    Asuthkar, Swapna
    Tsung, Andrew J.
    Velpula, Kiran K.
    PEERJ, 2020, 8
  • [8] Galectin-3 as a possible marker for increased thrombogenicity in COVID-19
    Puccini, M.
    Jakobs, K.
    Friebel, J.
    Reinshagen, L.
    Schencke, P. A.
    Haghikia, A.
    Landmesser, U.
    Kraenkel, N.
    Rauch, U.
    EUROPEAN HEART JOURNAL, 2022, 43 : 2653 - 2653
  • [9] Galectin-3: can it be a diagnostic tool for pneumonia in covid-19 patients?
    Baykan, Emine Kartal
    Sebin, Engin
    Karasahin, Omer
    Baykan, Ahmed Ramiz
    Cerrah, Serkan
    Gogebakan, Hasan
    Sevinc, Can
    Kahraman, Mustafa
    Yavuz, Yasemin Coskun
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2021, 51 (05) : 2256 - 2262
  • [10] Prognostic significance of serum galectin-3 in hospitalized patients with COVID-19
    Ozcan, Sevgi
    Donmez, Esra
    Yavuz, Sevil Tugrul
    Ziyrek, Murat
    Ince, Orhan
    Kucuk, H. Suat
    Tasdemir, Zeynep Atam
    Yilmaz, Ishak
    Varol, Sinan
    Sahin, Irfan
    Okuyan, Ertugrul
    CYTOKINE, 2022, 158
12345