Luminescence Tracking and In Vivo Toxicity Evaluation of TiO2 and Europium Doped TiO2 Nanocrystals during Drosophila Development

被引:4
|
作者
de Oliveira, Jerusa Maria [1 ,2 ]
da Silva, Kellen Talita Romao [2 ,3 ]
dos Santos, Francisco Rubens Alves [2 ,3 ]
Valer, Felipe Berti [4 ]
Takaki, Ricardo Kenji Ohno [4 ]
de Carvalho, Joao Paulo Santos [3 ]
de Castro, Olagide Wagner [5 ]
Rocha, Thiago Lopes [6 ]
Dantas, Noelio Oliveira [3 ]
Silva, Anielle Christine Almeida [1 ,3 ]
Anhezini, Lucas [2 ]
机构
[1] Univ Fed Alagoas, Chem Inst, Rede Nordeste Biotecnol RENORBIO, BR-57072900 Maceio, AL, Brazil
[2] Univ Fed Alagoas, Inst Biol & Hlth Sci, Lab In Vivo Anal Tox, BR-57072900 Maceio, AL, Brazil
[3] Univ Fed Alagoas, Phys Inst, Lab New Nanostruct & Funct Mat, BR-57072900 Maceio, AL, Brazil
[4] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, BR-14040900 Ribeirao Preto, SP, Brazil
[5] Univ Fed Alagoas, Inst Biol Sci & Hlth, Dept Physiol, BR-57072900 Maceio, AL, Brazil
[6] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Lab Environm Biotechnol & Ecotoxicol, BR-74690900 Goiania, GO, Brazil
关键词
nanotoxicology; TiO2 anatase phase; europium; Eu3+-doped TiO2; nanomaterials; fruit fly; metal doping; D; melanogaster; TITANIUM-DIOXIDE NANOPARTICLES; HYDROGEN-PEROXIDE; COMET ASSAY; SPOT TEST; MELANOGASTER; GENOTOXICITY; SILVER; SIZE; RISK;
D O I
10.3390/chemosensors11010055
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Titanium dioxide (TiO2) nanoparticles (NPs) are widely used in industry and commercial products. Thus, their potential risks to the environment and human health must be evaluated. Doping NPs with certain ions makes it possible to mix properties or generate new ones. Thus, in order to track TiO2 NPs in biological assays, doping with europium (Eu3+) ions was performed, which luminesce in red. Here, we synthesized TiO2 and Eu3+-doped TiO2 nanocrystals (NCs) in anatase phase to verify the toxicity at different concentrations in Drosophila melanogaster and track the distribution of these NCs in vivo. We verified that the incorporation of europium improved the biocompatibility in relation to the pure samples. The presence of Eu3+-doped TiO2 NCs in the gut, brain, and fat body of larvae and intestinal cells of adult animals was detected. Eu3+-doped TiO2 NCs caused significant larval and pupal mortality rates, in addition to leading to the formation of reactive species, especially at high concentrations. Therefore, our data demonstrated it was possible to trace the Eu3+-doped TiO2 NCs, but TiO2 and Eu3+-doped TiO2 NCs in anatase phase were toxic to fruit flies at the tested concentrations, and should be used with caution to minimize health risks.
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页数:14
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