RNA methylation in inflammatory bowel disease

被引：5

作者：

Ozato, Yuki ^{[1
,2
]}

Hara, Tomoaki ^{[1
]}

Meng, Sikun ^{[1
]}

Sato, Hiromichi ^{[1
,2
]}

Tatekawa, Shotaro ^{[3
]}

Uemura, Mamoru ^{[2
]}

Yabumoto, Takeshi ^{[4
]}

Uchida, Shizuka ^{[5
]}

Ogawa, Kazuhiko ^{[3
]}

Doki, Yuichiro ^{[2
]}

Eguchi, Hidetoshi ^{[2
]}

Ishii, Hideshi ^{[1
,6
]}

机构：

[1] Osaka Univ, Grad Sch Med, Ctr Med Innovat & Translat Res, Dept Med Data Sci, Suita, Japan

[2] Osaka Univ, Grad Sch Med, Dept Gastrointestinal Surg, Suita, Japan

[3] Osaka Univ, Grad Sch Med, Dept Radiat Oncol, Suita, Japan

[4] Kinshu Kai Med Corp, Osaka 5580041, Japan

[5] Aalborg Univ, Ctr RNA Med, Dept Clin Med, Copenhagen Sv, Denmark

[6] Osaka Univ, Grad Sch Med, Ctr Med Innovat & Translat Res, Dept Med Data Sci, Suita, Osaka 5650871, Japan

来源：

CANCER SCIENCE | 2024年 / 115卷 / 03期

关键词：

colorectal cancer; inflammatory bowel disease; m6A; methylation; RNA; MESSENGER-RNA; THERAPY; IDENTIFICATION; DEMETHYLASE; DIAGNOSIS; CONSENSUS; COLITIS;

D O I：

10.1111/cas.16048

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RNA modifications, including the renowned m6A, have recently garnered significant attention. This chemical alteration, present in mRNA, exerts a profound influence on protein expression levels by affecting splicing, nuclear export, stability, translation, and other critical processes. Although the role of RNA methylation in the pathogenesis and progression of IBD and colorectal cancer has been reported, many aspects remain unresolved. In this comprehensive review, we present recent studies on RNA methylation in IBD and colorectal cancer, with a particular focus on m6A and its regulators. We highlight the pivotal role of m6A in the pathogenesis of IBD and colorectal cancer and explore the potential applications of m6A modifications in the diagnosis and treatment of these diseases.

引用

页码：723 / 733

页数：11

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