New nitric oxide production inhibitors from Syzygium bullockii

被引：12

作者：

Tai, Bui Huu ^{[1
,2
]}

Ninh, Bui Hai ^{[2
,3
]}

Yen, Pham Hai ^{[1
]}

Dung, Duong Thi ^{[1
]}

Hoang, Nguyen Huy ^{[1
]}

Nhiem, Nguyen Xuan ^{[1
]}

Van Tuyen, Nguyen ^{[3
]}

Anh, Le Tuan ^{[4
]}

Kiem, Phan Van ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] VAST, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] Hai Phong Univ Med & Pharm, 72A Nguyen Binh Khiem, Hai Phong, Vietnam

[4] VAST, Mien Trung Inst Sci Res, Vietnam Natl Museum Nat, 321 Hue, Thua Thien Hu, Vietnam

来源：

JOURNAL OF NATURAL MEDICINES | 2023年 / 77卷 / 04期

关键词：

Syzygium bullockii; Myrtaceae; Triterpene glycoside; Syzybulloside; Nitric oxide inhibitor; GLYCOSIDES; BERGENIN; TANNINS; LEAVES;

D O I：

10.1007/s11418-023-01725-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three undescribed triterpene glycosides syzybullosides A-C (1-3) along with fourteen known compounds were isolated from the leaves of Syzygium bullockii (Hance) Merr. & L.M. Perry, including six triterpene glycosides (1-6), four phenolics (7-9, 17), four megastigmanes (10-13), and three flavonoids (14-16). The structures of 1-17 were elucidated by extensive spectroscopic analysis, including IR, HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-10 and 12-17 inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with IC50 values ranging from 1.30 to 13.70 mu M, lower than that of the positive control compound, L-NMMA (IC50 = 33.8 mu M).

引用

页码：964 / 971

页数：8

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