Finally neutralizing the threat? A novel SARS-CoV-2 vaccine platform that elicits enhanced neutralizing antibody responses

被引:0
|
作者
Salamango, Daniel J. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA
来源
MBIO | 2024年 / 15卷 / 04期
关键词
humoral immunity; pandemic; SARS-CoV-2; neutralizing antibodies; vaccines; DURATION; PROTEIN; SARS; COV;
D O I
10.1128/mbio.00067-24
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak took the world by storm due to its rapid global spread and unpredictable disease outcomes. The extraordinary ascension of SARS-CoV-2 to pandemic status motivated a world-wide effort to rapidly develop vaccines that could effectively suppress virus spread and mitigate severe disease. These efforts culminated in the development and deployment of several highly effective vaccines that were heralded as the beginning-of-the-end of the pandemic. However, these successes were short lived due to the unexpected and continuous emergence of more transmissible and immune-evasive SARS-CoV-2 variants. Thus, attention has shifted toward developing novel vaccine platforms that elicit more robust and sustained neutralizing antibody responses. Recent findings by Munoz-Alia and colleagues address this by combining a live recombinant measles vaccine platform with novel biochemical approaches to generate vaccine candidates that bolster the potency of neutralizing antibody responses against diverse SARS-CoV-2 spike proteins .
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页数:5
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