Advancements in dendritic cell vaccination: enhancing efficacy and optimizing combinatorial strategies for the treatment of glioblastoma

被引:2
|
作者
Subtirelu, Robert C. [1 ]
Teichner, Eric M. [2 ]
Ashok, Arjun [2 ]
Parikh, Chitra [2 ]
Talasila, Sahithi [2 ]
Matache, Irina-Mihaela [3 ]
Alnemri, Ahab G. [1 ]
Anderson, Victoria [2 ]
Shahid, Osmaan [1 ]
Mannam, Sricharvi [1 ]
Lee, Andrew [1 ]
Werner, Thomas [1 ]
Revheim, Mona-Elisabeth [4 ,5 ]
Alavi, Abass [1 ]
机构
[1] Hosp Univ Penn, Dept Radiol, Philadelphia, PA USA
[2] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA USA
[3] Carol Davila Univ Med & Pharm, Dept Physiol, Fac Med, Bucharest, Romania
[4] Oslo Univ Hosp, Div Orthoped Surg, Oslo, Norway
[5] Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway
来源
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词
glioblastoma; dendritic cell vaccination; positron emission tomography; antigen loading; immunotherapy; CYTOTOXIC T-LYMPHOCYTES; MALIGNANT GLIOMA; TUMOR-ANTIGEN; BRAIN-TUMOR; FDG-PET; MULTIFORME; VACCINES; IMMUNOTHERAPY; RESPONSES; SURVIVAL;
D O I
10.3389/fneur.2023.1271822
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Glioblastomas (GBM) are highly invasive, malignant primary brain tumors. The overall prognosis is poor, and management of GBMs remains a formidable challenge, necessitating novel therapeutic strategies such as dendritic cell vaccinations (DCVs). While many early clinical trials demonstrate an induction of an antitumoral immune response, outcomes are mixed and dependent on numerous factors that vary between trials. Optimization of DCVs is essential; the selection of GBM-specific antigens and the utilization of 18F-fludeoxyglucose Positron Emission Tomography (FDG-PET) may add significant value and ultimately improve outcomes for patients undergoing treatment for glioblastoma. This review provides an overview of the mechanism of DCV, assesses previous clinical trials, and discusses future strategies for the integration of DCV into glioblastoma treatment protocols. To conclude, the review discusses challenges associated with the use of DCVs and highlights the potential of integrating DCV with standard therapies.
引用
收藏
页数:12
相关论文
共 50 条
  • [41] Autologous tumor lysate-loaded dendritic cell vaccination in glioblastoma: What happened to the evidence?
    Olivier, T.
    Migliorini, D.
    REVUE NEUROLOGIQUE, 2023, 179 (05) : 502 - 505
  • [42] Enhancing Dendritic Cell Cancer Vaccination: The Synergy of Immune Checkpoint Inhibitors in Combined Therapies
    Zanotta, Serena
    Galati, Domenico
    De Filippi, Rosaria
    Pinto, Antonio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (14)
  • [43] Potential efficacy of dendritic cell immunomodulation in the treatment of osteoarthritis
    Alahdal, Murad
    Zhang, Hui
    Huang, Rongxiang
    Sun, Wei
    Deng, Zhiqin
    Duan, Li
    Ouyang, Hongwei
    Wang, Daping
    RHEUMATOLOGY, 2021, 60 (02) : 507 - 517
  • [44] Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment strategies
    Roth, Patrick
    Weller, Michael
    NEURO-ONCOLOGY, 2014, 16 : viii14 - viii19
  • [45] Combination Strategies to Optimize Efficacy of Dendritic Cell-Based Immunotherapy
    van Gulijk, Mandy
    Dammeijer, Floris
    Aerts, Joachim G. J. V.
    Vroman, Heleen
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [46] Strategies to improve the efficacy of Dendritic Cell-Based immunotherapy for Melanoma
    Hargadon, Kristian M.
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [47] ENHANCING IMMUNITY WHILE NEUTRALIZING T CELL-INDUCED IMMUNOSUPPRESSION THROUGH COMBINATORIAL IMMUNOTHERAPY OF GLIOBLASTOMA
    Zhai, L.
    Ladomersky, E.
    Gritsina, G.
    Lauing, K. L.
    Genet, M.
    Horbinski, C.
    Bloch, O.
    James, C. D.
    Wainwright, D. A.
    NEURO-ONCOLOGY, 2017, 19 : 18 - 18
  • [48] Efficacy of Schwann cell transplantation for spinal cord repair is improved with combinatorial strategies
    Bunge, Mary Bartlett
    JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (13): : 3533 - 3538
  • [49] Tetanus toxoid conditioning enhances migration and efficacy of dendritic cell vaccines in patients with glioblastoma
    Batich, Kristen
    Sampson, John H.
    Reap, Elizabeth
    Sanchez-Perez, Luis
    Archer, Gary
    Snyder, David
    Nair, Smita
    Gunn, Michael
    Mitchell, Duane
    JOURNAL OF NEUROSURGERY, 2015, 122 (06) : A1522 - A1522
  • [50] Dendritic vaccines - Fifth International Meeting - Dendritic cell vaccination and other strategies to tip the balance of the immune system
    Gabrilovich, Dmitry
    IDRUGS, 2007, 10 (10) : 699 - 702