Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels

被引：5
|
作者：
Li, Zhangqiang [1 ]
Cong, Ye [1 ]
Wu, Tong [1 ]
Wang, Tongtong [1 ]
Lou, Xinyao [1 ]
Yang, Xinyu [1 ]
Yan, Nieng [1 ,2 ]
机构：
[1] Tsinghua Univ, Beijing Frontier Res Ctr Biol Struct, Tsinghua Peking Joint Ctr Life Sci, Sch Life Sci,State Key Lab Membrane Biol, Beijing, Peoples R China
[2] Shenzhen Med Acad Res & Translat, Inst Bioarchitecture & Biointeract, Shenzhen, Guangdong, Peoples R China
来源：
CELL RESEARCH | 2024年 / 34卷 / 04期
基金：
中国国家自然科学基金;
关键词：
CALCIUM-CHANNELS;
D O I：
10.1038/s41422-024-00940-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：273 / 274
页数：2
相关论文
共 50 条
  • [31] Histamine H3 Receptor Activation Modulates Glutamate Release in the Corticostriatal Synapse by Acting at CaV2.1 (P/Q-Type) Calcium Channels and GIRK (KIR3) Potassium Channels
    Héctor Vázquez-Vázquez
    Carolina Gonzalez-Sandoval
    Ana V. Vega
    José-Antonio Arias-Montaño
    Jaime Barral
    Cellular and Molecular Neurobiology, 2022, 42 : 817 - 828
  • [32] Structure-activity relationship of ω-agatoxin-TK, a peptide blocker of P/Q-type calcium channels
    Watanabe, T
    Kuwada, M
    Nishizawa, Y
    Kumagaye, KY
    Nakajima, K
    Asakawa, N
    PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, : 271 - 273
  • [33] Solid-phase Synthesis of ω-Agatoxin IVA, a P-type Calcium Channel Blocker
    Najib, Jamila
    Letailleur, Thierry
    Gesquiere, Jean-Claude
    Tartar, Andre
    JOURNAL OF PEPTIDE SCIENCE, 1996, 2 (05) : 309 - 317
  • [34] The Cav2.1/α1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells
    Stephens, GJ
    Morris, NP
    Fyffe, REW
    Robertson, B
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (10) : 1902 - 1912
  • [35] The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Cav2.1) calcium channels expressed in human embryonic kidney cells
    Melliti, K
    Grabner, M
    Seabrook, GR
    JOURNAL OF PHYSIOLOGY-LONDON, 2003, 546 (02): : 337 - 347
  • [36] P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb
    Pyrski, Martina
    Tusty, Mahbuba
    Eckstein, Eugenia
    Oboti, Livio
    Rodriguez-Gil, Diego J.
    Greer, Charles A.
    Zufall, Frank
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2018, 12
  • [37] Binding of Gαo N-terminus is responsible for the voltage-resistant inhibition of α1A (Q-type, Cav2.1) Ca2+ channels
    Kinoshita, M
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2002, 122 (08): : 565 - 572
  • [38] FRET two-hybrid analysis reveals differences in the interaction of calmodulin with CaV1.2 (L-) versus CaV2.1 (P/Q-type) Ca channels (vol 86, pg 275a, 2004)
    Evans, J
    Tay, LH
    Mori, MX
    Anderson, M
    Erickson, MG
    Yue, DT
    BIOPHYSICAL JOURNAL, 2004, 86 (04) : 2634 - 2634
  • [39] N- and P/Q-type calcium channels
    不详
    DRUG DISCOVERY TODAY, 2001, 6 (06) : 326 - 327
  • [40] P/Q-type Ca2+ channel blocker ω-agatoxin IVA protects against brain injury after focal ischemia in rats
    Asakura, K
    Matsuo, Y
    Kanemasa, T
    Ninomiya, M
    BRAIN RESEARCH, 1997, 776 (1-2) : 140 - 145
12345