Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

被引：5
|
作者：
Liu, Yuan [1 ]
Qu, Juan [2 ]
Xu, Junjie [2 ]
Gu, Aiming [2 ]
Deng, Dezhi [2 ]
Jia, Xiaodan [2 ]
Wang, Baoxiang [2 ]
机构：
[1] Zhejiang Chinese Med Univ, Jiaxing Univ Master Degree Cultivat Base, Jiaxing, Peoples R China
[2] Jiaxing Univ, Hosp Jiaxing 1, Dept Neurol, Affiliated Hosp, Jiaxing, Peoples R China
来源：
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词：
ischemic stroke; trimethylamine-N-oxide; gut microbiota; trimethylamine; stroke; GUT MICROBIOTA; L-CARNITINE; METABOLISM; SUPPLEMENTATION; ASSOCIATION; THROMBOSIS; INCREASES;
D O I：
10.3389/fneur.2023.1156879
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly associated with the risk of stroke, as well as the severity and prognosis of stroke; however, this conclusion remains contentious. This article reviews the production of TMAO, TMAO's relationship with different etiological types of ischemic stroke, and the possibility of reducing TMAO levels to improve the prognosis of ischemic stroke.
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页数：8
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