A PEDOT enhanced covalent organic framework (COF) fluorescent probe for in vivo detection and imaging of Fe3+

被引:5
|
作者
Zhen, Deshuai [1 ,2 ]
Zhang, Shaoqi [1 ,2 ]
Yang, Aofeng [1 ]
Li, Le [1 ]
Cai, Qingyun
Grimes, Craig A. [3 ]
Liu, Yu [1 ,2 ,4 ]
机构
[1] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China
[2] Hunan Univ, Sch Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
[3] Flux Photon Corp, 5950 Shiloh Rd East, Alpharetta, GA 30005 USA
[4] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China
基金
中国国家自然科学基金;
关键词
Covalent organic framework; Fluorescent probe; In vivo imaging; CARBON DOTS; SELECTIVE DETECTION; CHROMATOGRAPHY; PLATFORM; STORAGE; CU2+; IONS;
D O I
10.1016/j.ijbiomac.2023.129104
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Simple and accurate in vivo monitoring of Fe3+ is essential for gaining a better understanding of its role in physiological and pathological processes. A novel fluorescent probe was synthesized via in situ solid-state polymerization of 3,4-ethylenedioxythiophene (PEDOT) in the pore channels of a covalent organic framework (COF). The PEDOT@COF fluorescent probe exhibited an absolute quantum yield (QY) 3 times higher than COF. In the presence of Fe3+ the PEDOT@COF 475 nm fluorescence emission, 365 nm excitation, is quenched within 180 s. Fluorescence quenching is linear with Fe3+ in the concentration range of 0-960 mu M, with a detection limit of 0.82 mu M. The fluorescence quenching mechanism was attributed to inner filter effect (IEF), photoinduced electron transfer (PET) and static quenching (SQE) between PEDOT@COF and Fe3+. A paper strip-based detector was designed to facilitate practical applicability, and the PEDOT@COF probe successfully applied to fluorescence imaging of Fe3+ levels in vivo. This work details a tool of great promise for enabling detailed investigations into the role of Fe3+ in physiological and pathological diseases.
引用
收藏
页数:11
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