Intestinal Colonization of Campylobacter jejuni and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens
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作者:
Chagneau, Sophie
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Univ Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Univ Montreal, Fac Medecine Vet, Swine & Poultry Infect Dis Res Ctr, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, CanadaUniv Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Chagneau, Sophie
[1
,2
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Gaucher, Marie-Lou
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Univ Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Univ Montreal, Fac Medecine Vet, Swine & Poultry Infect Dis Res Ctr, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, CanadaUniv Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Gaucher, Marie-Lou
[1
,2
]
Fravalo, Philippe
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Chaire Agroalimentaire Conservatoire Natl Arts & M, F-22440 Ploufragan, FranceUniv Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Fravalo, Philippe
[3
]
Theriault, William P. P.
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Univ Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Univ Montreal, Fac Medecine Vet, Swine & Poultry Infect Dis Res Ctr, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, CanadaUniv Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Theriault, William P. P.
[1
,2
]
Thibodeau, Alexandre
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Univ Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Univ Montreal, Fac Medecine Vet, Swine & Poultry Infect Dis Res Ctr, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Univ Montreal, Ctr Rech Sante Publ CReSP, Montreal, PQ H3N 1X9, CanadaUniv Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
Thibodeau, Alexandre
[1
,2
,4
]
机构:
[1] Univ Montreal, Fac Medecine Vet, Res Chair Meat Safety, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
[2] Univ Montreal, Fac Medecine Vet, Swine & Poultry Infect Dis Res Ctr, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada
[3] Chaire Agroalimentaire Conservatoire Natl Arts & M, F-22440 Ploufragan, France
Campylobacter jejuni is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between C. jejuni and the chicken immune system, especially in the context of hepatic dissemination. Therefore, to follow up on our previous study showing intestinal colonization and hepatic spread of C. jejuni, cecal tonsils and liver samples were collected from these birds to determine the mRNA levels of chemokines and cytokines. Serum samples were also collected to determine serum amyloid A (SAA) concentrations and specific IgY titers. Lack of Th17 induction was observed in the cecal tonsils of only the liver-contaminated groups. This hepatic dissemination was accompanied by innate, Th1 and Th2 immune responses in livers, as well as an increase in SAA concentrations and specific IgY levels in sera. Campylobacter appears to be able to restrain the induction of the chicken gut immunity in particular conditions, possibly enhancing its hepatic dissemination and thus eliciting systemic immune responses. Although Campylobacter is often recognized as a commensal-like bacterium in chickens, it seems to modulate the gut immune system and induce systemic immunity.
机构:
Univ Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, AustriaUniv Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, Austria
Ruhnau, Daniel
Hess, Claudia
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Univ Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, AustriaUniv Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, Austria
Hess, Claudia
Doupovec, Barbara
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BIOMIN Res Ctr, Technopk 1, Tulln, AustriaUniv Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, Austria
Doupovec, Barbara
Grenier, Bertrand
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BIOMIN Res Ctr, Technopk 1, Tulln, AustriaUniv Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, Austria
Grenier, Bertrand
Schatzmayr, Dian
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BIOMIN Res Ctr, Technopk 1, Tulln, AustriaUniv Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, Austria
Schatzmayr, Dian
Hess, Michael
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Univ Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, AustriaUniv Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, Austria
Hess, Michael
Awad, Wageha
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Univ Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, AustriaUniv Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vet Pl 1, A-1210 Vienna, Austria