The Role of Seminal Oxidative Stress in Recurrent Pregnancy Loss

被引:5
|
作者
Davies, Rhianna [1 ]
Jayasena, Channa N. N. [1 ]
Rai, Raj [2 ]
Minhas, Suks [3 ]
机构
[1] Imperial Coll London, Dept Metab Digest & Reprod, London W12 0NN, England
[2] Imperial Coll NHS Trust, St Marys Hosp, Dept Obstet & Gynaecol, London W2 1NY, England
[3] Imperial Coll NHS Trust, Charing Cross Hosp, Dept Urol, London W6 8RF, England
基金
英国生物技术与生命科学研究理事会;
关键词
recurrent pregnancy loss; sperm DNA damage; reactive oxygen species; ROS; antioxidants; SPERM DNA FRAGMENTATION; CHROMATIN-STRUCTURE ASSAY; MALE FACTOR INFERTILITY; SEMEN PARAMETERS; SPONTANEOUS-ABORTION; VARICOCELE REPAIR; INTEGRITY; ANTIOXIDANTS; COUPLES; IMPACT;
D O I
10.3390/antiox12030723
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recurrent pregnancy loss is a distressing condition affecting 1-2% of couples. Traditionally investigations have focused on the female, however more recently researchers have started to explore the potential contribution of the male partner. Seminal reactive oxygen species have a physiological function in male reproduction but in excess are suspected to generate structural and functional damage to the sperm. Evidence is mounting to support an association between elevated seminal reaction oxygen species and recurrent pregnancy loss. Studies suggest that the rates of sperm DNA damage are higher in the male partners of women affected by recurrent pregnancy loss compared with unaffected men. However, the available pool of data is conflicting, and interpretation is limited by the recent change in nomenclature and the heterogeneity of study methodologies. Furthermore, investigation into the effects of oxidative stress on the epigenome show promise. The value of antioxidant therapy in the management of recurrent pregnancy loss currently remains unclear.
引用
收藏
页数:12
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