Phage therapy: From biological mechanisms to future directions

被引：171
|
作者：
Strathdee, Steffanie A. [1 ]
Hatfull, Graham F. [2 ]
Mutalik, Vivek K. [3 ]
Schooley, Robert T. [1 ]
机构：
[1] Univ Calif San Diego, Ctr Innovat Phage Applicat & Therapeut, Div Infect Dis & Global Publ Hlth, La Jolla, CA 92093 USA
[2] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA
[3] Lawrence Berkeley Natl Lab, Environm Genom & Syst Biol Div, Berkeley, CA 94720 USA
来源：
CELL | 2023年 / 186卷 / 01期
关键词：
BACTERIOPHAGE; EVOLUTION; INFECTION;
D O I：
10.1016/j.cell.2022.11.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural pred-ators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) pref-erably be lytic, (2) kill the bacterial host efficiently, and (3) be fully characterized to exclude side effects. Devel-oping therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review the state of the art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, and future directions involving naturally occurring and genetically modified or synthetic phages.
引用
收藏
页码：17 / 31
页数：15
相关论文
共 50 条
  • [31] Trust in adolescence: Development, mechanisms and future directions
    Krabbendam, Lydia
    Sijtsma, Hester
    Crone, Eveline A.
    van Buuren, Mariet
    [J]. DEVELOPMENTAL COGNITIVE NEUROSCIENCE, 2024, 69
  • [32] Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions
    Hao, Yan
    Zhu, Ya-juan
    Zou, Song
    Zhou, Pei
    Hu, Ya-wen
    Zhao, Qi-xiang
    Gu, Lin-na
    Zhang, Hao-zhou
    Wang, Zhen
    Li, Jiong
    [J]. FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [33] PrPostoperative ileus: mechanisms and future directions for research
    Vather, Ryash
    O'Grady, Greg
    Bissett, Ian P.
    Dinning, Phil G.
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2014, 41 (05) : 358 - 370
  • [34] Stress and cancer: mechanisms, significance and future directions
    Anabel Eckerling
    Itay Ricon-Becker
    Liat Sorski
    Elad Sandbank
    Shamgar Ben-Eliyahu
    [J]. Nature Reviews Cancer, 2021, 21 : 767 - 785
  • [35] Current and Future Directions for Angiosarcoma Therapy
    Vaia Florou
    Breelyn A. Wilky
    [J]. Current Treatment Options in Oncology, 2018, 19
  • [36] Future Directions of Flow Diverter Therapy
    Chiu, Albert Ho Yuen
    Phillips, Timothy John
    [J]. NEUROSURGERY, 2020, 86 : S106 - S116
  • [37] Failed therapy and directions for the future in dyspepsia
    Holtmann, Gerald
    Gapasin, Judith
    [J]. DIGESTIVE DISEASES, 2008, 26 (03) : 218 - 224
  • [38] Current and Future Directions for Angiosarcoma Therapy
    Florou, Vaia
    Wilky, Breelyn A.
    [J]. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2018, 19 (03)
  • [39] Controversies and future directions in the therapy of lymphoma
    Connors, JM
    [J]. LEUKEMIA & LYMPHOMA, 1998, 30 : 1 - 2
  • [40] FUTURE DIRECTIONS IN LIGHT THERAPY RESEARCH
    Redd, William
    [J]. INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 2018, 25 : S92 - S92
12345