Phage therapy: From biological mechanisms to future directions

被引：171

作者：

Strathdee, Steffanie A. ^{[1
]}

Hatfull, Graham F. ^{[2
]}

Mutalik, Vivek K. ^{[3
]}

Schooley, Robert T. ^{[1
]}

机构：

[1] Univ Calif San Diego, Ctr Innovat Phage Applicat & Therapeut, Div Infect Dis & Global Publ Hlth, La Jolla, CA 92093 USA

[2] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

[3] Lawrence Berkeley Natl Lab, Environm Genom & Syst Biol Div, Berkeley, CA 94720 USA

来源：

CELL | 2023年 / 186卷 / 01期

关键词：

BACTERIOPHAGE; EVOLUTION; INFECTION;

D O I：

10.1016/j.cell.2022.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural pred-ators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) pref-erably be lytic, (2) kill the bacterial host efficiently, and (3) be fully characterized to exclude side effects. Devel-oping therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review the state of the art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, and future directions involving naturally occurring and genetically modified or synthetic phages.

引用

页码：17 / 31

页数：15

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