The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer's Disease and Possible Mechanisms

被引：0

作者：

Tekin, Esra ^{[1
]}

Kucuk, Aysegul ^{[1
]}

Arslan, Mustafa ^{[2
,3
,4
]}

机构：

[1] Kutahya Hlth Sci Univ, Fac Med, Dept Physiol, Kutahya, Turkiye

[2] Gazi Univ, Fac Med, Dept Anesthesiol & Reanimat, Ankara, Turkiye

[3] Gazi Univ, Life Sci Applicat & Res Ctr, Ankara, Turkiye

[4] Gazi Univ, Lab Anim Breeding & Expt Res Ctr GUDAM, Ankara, Turkiye

来源：

GAZI MEDICAL JOURNAL | 2023年 / 35卷 / 01期

关键词：

Alzheimer's disease; dyshomeostasis; iron; copper; zinc; magnesium; PRECURSOR PROTEIN TRANSLATION; CEREBROSPINAL-FLUID; TRACE-ELEMENTS; BRAIN; SERUM; DEMENTIA; PLASMA;

D O I：

10.4274/gmj.galenos.2023.3865

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease (AD) affects many people around the world, and its incidence is increasing. In addition to the amyloid cascade hypothesis, different mechanisms are discussed for AD, which has no definitive treatment. Studies have shown that the levels of metal cations such as iron, copper, zinc, and magnesium vary and their metabolism are impaired in patients with AD. Metal cation dyshomeostasis is believed to be one of the mechanisms that contribute to the development of AD. In this review, we aimed to evaluate various metal cations in terms of AD.

引用

页码：100 / 105

页数：6

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