Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

被引:31
|
作者
Radulescu, Diana-Elena [1 ]
Vasile, Otilia Ruxandra [1 ,2 ,3 ]
Andronescu, Ecaterina [1 ,2 ,3 ]
Ficai, Anton [1 ,2 ,3 ]
机构
[1] Bucharest Natl Polytech Univ Sci & Technol, Fac Chem Engn & Biotechnol, Dept Sci & Engn Oxide Mat & Nanomat, Bucharest 011061, Romania
[2] Bucharest Natl Polytech Univ Sci & Technol, Natl Res Ctr Micro & Nanomat, Bucharest 060042, Romania
[3] Romanian Acad Scientists, Bucharest 050045, Romania
关键词
hydroxyapatite; doping; bone tissue engineering; biocompatibility; mechanical properties; MICROWAVE-ASSISTED SYNTHESIS; IN-VITRO BIOCOMPATIBILITY; MECHANICAL-PROPERTIES; SUBSTITUTED HYDROXYAPATITE; ANTIMICROBIAL ACTIVITY; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; CALCIUM HYDROXYAPATITE; ANTIBACTERIAL ACTIVITY; COATINGS;
D O I
10.3390/ijms241713157
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field.
引用
收藏
页数:32
相关论文
共 50 条
  • [31] Freeze casting of hydroxyapatite scaffolds for bone tissue engineering
    Deville, Sylvain
    Saiz, Eduardo
    Tomsia, Antoni P.
    BIOMATERIALS, 2006, 27 (32) : 5480 - 5489
  • [32] Frontiers of Hydroxyapatite Composites in Bionic Bone Tissue Engineering
    Shi, Jingcun
    Dai, Wufei
    Gupta, Anand
    Zhang, Bingqing
    Wu, Ziqian
    Zhang, Yuhan
    Pan, Lisha
    Wang, Lei
    MATERIALS, 2022, 15 (23)
  • [33] Laser Surface Engineering of Hierarchy Hydroxyapatite Aerogel for Bone Tissue Engineering
    Parandoush, Pedram
    Fan, Hanxiong
    Song, Xiaolei
    Lin, Dong
    JOURNAL OF MICRO AND NANO-MANUFACTURING, 2018, 6 (01):
  • [34] LASER SURFACE ENGINEERING OF HIERACHY HYDROXYAPATITE AEROGEL FOR BONE TISSUE ENGINEERING
    Parandoush, Pedram
    Fan, Hanxiong
    Song, Xiaolei
    Lin, Dong
    PROCEEDINGS OF THE ASME 12TH INTERNATIONAL MANUFACTURING SCIENCE AND ENGINEERING CONFERENCE - 2017, VOL 1, 2017,
  • [35] Extraction of Hydroxyapatite from Camel Bone for Bone Tissue Engineering Application
    Khurshid, Zohaib
    Alfarhan, Mohammed Farhan
    Mazher, Javed
    Bayan, Yasmin
    Cooper, Paul R.
    Dias, George J.
    Adanir, Necdet
    Ratnayake, Jithendra
    MOLECULES, 2022, 27 (22):
  • [36] Boron nitride nanofiber/Zn-doped hydroxyapatite/polycaprolactone scaffolds for bone tissue engineering applications
    Turhan, Emine Ayse
    Akbaba, Sema
    Tezcaner, Aysen
    Evis, Zafer
    BIOMATERIALS ADVANCES, 2023, 148
  • [37] Magnetic poly(ε-caprolactone)/iron-doped hydroxyapatite nanocomposite substrates for advanced bone tissue engineering
    Gloria, A.
    Russo, T.
    D'Amora, U.
    Zeppetelli, S.
    D'Alessandro, T.
    Sandri, M.
    Banobre-Lopez, M.
    Pineiro-Redondo, Y.
    Uhlarz, M.
    Tampieri, A.
    Rivas, J.
    Herrmannsdoerfer, T.
    Dediu, V. A.
    Ambrosio, L.
    De Santis, R.
    JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2013, 10 (80)
  • [38] Antibacterial and Cellular Behaviors of Novel Zinc-Doped Hydroxyapatite/Graphene Nanocomposite for Bone Tissue Engineering
    Maleki-Ghaleh, H.
    Siadati, M. H.
    Fallah, A.
    Koc, B.
    Kavanlouei, M.
    Khademi-Azandehi, P.
    Moradpur-Tari, E.
    Omidi, Y.
    Barar, J.
    Beygi-Khosrowshahi, Y.
    Kumar, Alan P.
    Adibkia, K.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (17)
  • [39] Bacterial cellulose-reinforced boron-doped hydroxyapatite/gelatin scaffolds for bone tissue engineering
    Atila, Deniz
    Karatas, Ayten
    Evcin, Atilla
    Keskin, Dilek
    Tezcaner, Aysen
    CELLULOSE, 2019, 26 (18) : 9765 - 9785
  • [40] Systematic investigation and controlled synthesis of Ag/Ti co-doped hydroxyapatite for bone tissue engineering
    Gergeroglu, Hazal
    Ebeoglugil, Mehmet Faruk
    Bayrak, Sule
    Aksu, Didem
    Azar, Yavar Taghipour
    MATERIALS TODAY CHEMISTRY, 2024, 39