Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

被引:31
|
作者
Radulescu, Diana-Elena [1 ]
Vasile, Otilia Ruxandra [1 ,2 ,3 ]
Andronescu, Ecaterina [1 ,2 ,3 ]
Ficai, Anton [1 ,2 ,3 ]
机构
[1] Bucharest Natl Polytech Univ Sci & Technol, Fac Chem Engn & Biotechnol, Dept Sci & Engn Oxide Mat & Nanomat, Bucharest 011061, Romania
[2] Bucharest Natl Polytech Univ Sci & Technol, Natl Res Ctr Micro & Nanomat, Bucharest 060042, Romania
[3] Romanian Acad Scientists, Bucharest 050045, Romania
关键词
hydroxyapatite; doping; bone tissue engineering; biocompatibility; mechanical properties; MICROWAVE-ASSISTED SYNTHESIS; IN-VITRO BIOCOMPATIBILITY; MECHANICAL-PROPERTIES; SUBSTITUTED HYDROXYAPATITE; ANTIMICROBIAL ACTIVITY; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; CALCIUM HYDROXYAPATITE; ANTIBACTERIAL ACTIVITY; COATINGS;
D O I
10.3390/ijms241713157
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field.
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页数:32
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