p-TSA Catalyzed One-Pot Synthesis of 2-(1H-Indol-3-yl)-3-Phenylquinazolin-4(3H)-Ones

被引：5
|
作者：
Tamilselvi, Velmurugan [1 ]
Ramesh, Rathinam [2 ]
Lalitha, Appaswami [1 ]
机构：
[1] Periyar Univ, Dept Chem, Salem 636011, Tamil Nadu, India
[2] Sona Coll Arts & Sci, Dept Chem, Salem, Tamil Nadu, India
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 01期
关键词：
p-TSA; 2-(1H-indol-3-yl)-3-phenylquinazolin-4(3H)-ones; one-pot; multicomponent; MEDICINAL SCAFFOLDS; DERIVATIVES; QUINAZOLINONE; ANTICANCER; EFFICIENT;
D O I：
10.1080/10406638.2021.2015399
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we wish to report a p-TSA catalyzed synthesis of a new series of 2-(1H-indol-3-yl)-3-phenylquinazolin-4(3H)-ones in methanol at reflux condition. The present protocol has the advantages of simple work up, high yield with shorter reaction time, inexpensive catalyst, easily available starting materials and no need of chromatographic purification. The products were characterized by various spectral techniques.
引用
收藏
页码：434 / 443
页数：10
相关论文
共 50 条
  • [41] Vilsmeier Reaction of 3-Aminopropenamides: One-Pot Synthesis of Pyrimidin-4(3H)-ones
    Zhang, Rui
    Zhang, Dingyuan
    Liang, Yongjiu
    Zhou, Guangyuan
    Dong, Dewen
    JOURNAL OF ORGANIC CHEMISTRY, 2011, 76 (08): : 2880 - 2883
  • [42] 3-(1H-indol-3-yl)-2-[3-(4-methoxybenzoyl)-thioureido]propionic acid
    Ngah, N
    Dariman, N
    Yamin, BM
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O1025 - O1027
  • [43] Efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones from aromatic aldehydes and their one-pot oxidation to quinazolin-4(3H)-ones catalyzed by Bi(NO3)3•5H2O: Investigating the role of the catalyst
    Mohammadpoor-Baltork, Iraj
    Khosropour, Ahmad R.
    Moghadam, Majid
    Tangestaninejad, Shahram
    Mirkhani, Valiollah
    Baghersad, Saeid
    Mirjafari, Arsalan
    COMPTES RENDUS CHIMIE, 2011, 14 (10) : 944 - 952
  • [44] 3,3-bis(1H-indol-3-yl)indolin-2-one
    Selvanayagam, S
    Chandak, MS
    Velmurugan, D
    Ravikumar, K
    Raghunathan, R
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 : O3122 - O3123
  • [45] 2,2-Bis(1H-indol-3-yl)indolin-3-one
    Li, Zhao-Hao
    Xu, Jing
    Wu, Wen-Liang
    Su, Wei-Ping
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1353 - U2513
  • [46] Zirconyl(IV) Chloride Catalyzed Three Component One-pot Synthesis of Quinazolin-4(3H)-ones
    Jaiprakash N. Sangshetti
    Nagnnath D. Kokare
    Devanand B. Shinde
    Monatshefte für Chemie - Chemical Monthly, 2007, 138 : 1289 - 1291
  • [47] Zirconyl(IV) chloride catalyzed three component one-pot synthesis of quinazolin-4(3H)-ones
    Sangshetti, Jaiprakash N.
    Kokare, Nagnnath D.
    Shinde, Devanand B.
    MONATSHEFTE FUR CHEMIE, 2007, 138 (12): : 1289 - 1291
  • [48] L-PROLINE-CATALYZED KNOEVENAGEL CONDENSATION: A FACILE, GREEN SYNTHESIS OF (E)-ETHYL 2-CYANO-3-(1H-INDOL-3-YL)ACRYLATES AND (E)-3-(1H-INDOL-3-YL)ACRYLONITRILES
    Venkatanarayana, M.
    Dubey, P. K.
    SYNTHETIC COMMUNICATIONS, 2012, 42 (12) : 1746 - 1759
  • [49] Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives
    Rhee, Hee-Kyung
    Yoo, Ji Hye
    Lee, Eunyoung
    Kwon, Young Joo
    Seo, Hang-Rhan
    Lee, Yun-Sil
    Choo, Hea-Young Park
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) : 3900 - 3908
  • [50] Domino [Pd]-Catalysis: One-Pot Synthesis of Isobenzofuran-1 (3H)-ones
    Mahendar, Lodi
    Satyanarayana, Gedu
    JOURNAL OF ORGANIC CHEMISTRY, 2016, 81 (17): : 7685 - 7691
12345