Severe Enteritis after Cyclophosphamide Administration in a Patient with Microscopic Polyangiitis: A Case Report and Literature Review

被引：0

作者：

Yoshida, Shuhei ^{[1
]}

Temmoku, Jumpei ^{[1
]}

Asano, Tomoyuki ^{[1
]}

Iwasaki, Tsuyoshi ^{[2
]}

Matsumoto, Haruki ^{[1
]}

Fujita, Yuya ^{[1
]}

Yashiro-Furuya, Makiko ^{[1
]}

Matsuoka, Naoki ^{[1
]}

Gunji, Naohiko ^{[3
]}

Sato, Shuzo ^{[1
]}

Watanabe, Hiroshi ^{[1
]}

Ohira, Hiromasa

Migita, Kiyoshi ^{[1
]}

机构：

[1] Fukushima Med Univ, Sch Med, Dept Rheumatol, Fukushima, Japan

[2] Fukushima Med Univ, Sch Med, Dept Nephrol & Hypertens, Fukushima, Japan

[3] Fukushima Med Univ, Sch Med, Dept Gastroenterol, Fukushima, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 09期

关键词：

cyclophosphamide; enteritis; microscopic polyangiitis; TOXICITY; COLITIS;

D O I：

10.2169/internalmedicine.0434-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe enteritis is a rare side effect of cyclophosphamide (CPA) therapy, and only two cases have been reported to date. We herein report a 60-year-old man who developed severe enteritis after intravenous CPA administration for microscopic polyangiitis. He was successfully treated by discontinuation of CPA administration and long-term intensive supportive care. A diagnosis of CPA-associated enteritis was made based on the clinical course and imaging and pathological findings. This review of three cases of CPA-related enteritis, including our case, suggests that prompt CPA discontinuation and intensive systemic management are necessary when patients have gastrointestinal symptoms after CPA administration.

引用

页码：1279 / 1285

页数：7

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