Exploiting Iron Metabolism as a Therapeutic Vulnerability in Glioblastoma

被引：3
|
作者：
Nabavizadeh, Ali [1 ,3 ]
Bagley, Stephen J. [2 ]
机构：
[1] Univ Penn, Hosp Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA USA
[2] Univ Penn, Abramson Canc Ctr, Philadelphia, PA USA
[3] Hosp Univ Penn, Dept Radiol, Silverstein Bldg 3400 Spruce St, Philadelphia, PA 19104 USA
来源：
CLINICAL CANCER RESEARCH | 2024年 / 30卷 / 02期
关键词：
D O I：
10.1158/1078-0432.CCR-23-3027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this CCR Translations, we discuss pharmacologic ascorbate as a novel therapeutic for glioblastoma (GBM). Aberrant iron metabolism in GBM can be assessed noninvasively by MRI and exploited to potentially improve the efficacy of chemoradiotherapy. We contextualize the study's results and discuss the next steps to further develop this paradigm.
引用
收藏
页码：255 / 256
页数：2
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