Generation of induced pluripotent stem cells (ZZUCSBi001-A) from skin fibroblasts of a healthy donor

被引：0

作者：

Li, Shu-Ang ^{[1
]}

Zhang, Ying-Jie ^{[1
,2
]}

Zhu, Yong-Qing ^{[1
,2
]}

Meng, Xiao-Yan ^{[1
,2
]}

Chen, Cai-Li ^{[3
]}

Liu, Pei -Pei ^{[1
]}

Sun, Wei ^{[4
]}

机构：

[1] Zhengzhou Univ, Clin Syst Biol Labs, Affiliated Hosp 1, 1 Longhu Middle Ring Rd, Zhengzhou 450052, Peoples R China

[2] Zhengzhou Univ, Acad Med Sci, Zhengzhou 450001, Peoples R China

[3] Xinxiang Med Univ, Sch Basic Med Sci, Dept Immunol, Xinxiang 453003, Henan, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Burn & Repair Reconstruct Surg, Zhengzhou 450052, Peoples R China

来源：

STEM CELL RESEARCH | 2024年 / 76卷

关键词：

D O I：

10.1016/j.scr.2024.103328

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Fibroblasts were extracted from the scalp of a healthy 55 -year -old male and subsequently transformed into pluripotent stem cells by introducing episomal plasmids harboring essential reprogramming factors. These induced pluripotent stem cells exhibited a normal karyotype and demonstrated the capacity to differentiate into all three germ layers, as confirmed through teratoma assays. This specific cell line serves as a valuable reference for comparative investigations alongside other induced pluripotent stem cell lines generated from somatic cells of patients afflicted by genetic neurodegenerative disorders.

引用

页数：4

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