Reversible cardiomyopathy after interferon-gamma for cutaneous T cell lymphoma: A report of two cases

被引：0
|
作者：
Durgin, Joseph S. [1 ]
Jariwala, Neha N. [2 ]
Rook, Alain H. [2 ]
Ortega-Legaspi, Juan M. [3 ,4 ]
机构：
[1] Univ Michigan, Dept Dermatol, Ann Arbor, MI USA
[2] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA USA
[3] Univ Penn, Perelman Sch Med, Div Cardiol, Adv Heart Failure & Transplantat Sect, Philadelphia, PA USA
[4] Perelman Ctr Adv Med, South 11-150,3400 Civ Ctr Blvd,722 Perelman South, Philadelphia, PA 19104 USA
来源：
CURRENT PROBLEMS IN CANCER: CASE REPORTS | 2023年 / 11卷
关键词：
Interferon; Cardiomyopathy; Heart failure; Lymphoma; T cell; Immunotherapy; CARDIOTOXICITY; SUNITINIB;
D O I：
10.1016/j.cpccr.2023.100255
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interferons are widely expressed cytokines that possess potent anti-viral and anti-tumor activity. As therapeutic agents, interferons have proven useful in treating assorted cancers, chronic infections, and autoimmune disease. However, interferon therapy has well-known adverse effects, including flu-like symptoms, depression, triggering of autoimmune phenomena, and dose-dependent cytopenias. In this report, we describe two cases of congestive heart failure occurring after treatment with interferon-gamma (a type II interferon) for advanced cutaneous T cell lymphoma. Based on existing mechanistic studies, both the potentiation of autoimmunity and the direct cytotoxic effects of interferons on the myocardium may account for this uncommon adverse effect of interferon therapy.
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页数：3
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