Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation

被引：3

作者：

Baek, Dong Won ^{[1
]}

Moon, Joon Ho ^{[1
]}

Lee, Jae Hoon ^{[2
]}

Kang, Ka-Won ^{[3
]}

Lee, Ho Sup ^{[4
]}

Eom, Hyeon-Seok ^{[5
]}

Lee, Enuyoung ^{[5
]}

Lee, Ji Hyun ^{[6
]}

Lee, Jeong-Ok ^{[7
]}

Park, Seong Kyu ^{[8
]}

Kim, Seok Jin ^{[9
]}

Yoo, Keon Hee ^{[10
]}

Yoon, Sung-Soo ^{[11
]}

Koh, Youngil ^{[11
]}

Kang, Hyoung Jin ^{[12
]}

Won, Jong-Ho ^{[13
]}

Lyu, Chuhl Joo ^{[14
]}

Hahn, Seung Min ^{[14
]}

Lee, Jung-Hee ^{[15
]}

Park, Joon Seong ^{[16
]}

Jo, Jae-Cheol ^{[17
]}

Mun, Yeung-Chul ^{[18
]}

Yang, Deok-Hwan ^{[19
]}

Song, Ga-Young ^{[19
]}

Lim, Sung-Nam ^{[20
]}

Sohn, Sang Kyun ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea

[2] Gachon Univ, Hematol, Gil Med Ctr, Incheon, South Korea

[3] Korea Univ, Dept Internal Med, Div Hematol Oncol, Coll Med, Seoul, South Korea

[4] Kosin Univ, Gospel Hosp, Dept Internal Med, Div Hematol,Coll Med, Pusan, South Korea

[5] Natl Canc Ctr, Ctr Hematol Malignancy, Seoul, South Korea

[6] Dong A Univ, Dept Internal Med, Div Hematol Oncol, Coll Med, Busan, South Korea

[7] Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seoul, South Korea

[8] Soonchunhyang Univ, Dept Internal Med, Div Hematol Oncol, Bucheon Hosp, Bucheon, South Korea

[9] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, Seoul, South Korea

[10] Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea

[11] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

[12] Seoul Natl Univ, Seoul Natl Univ Canc Res Inst, Seoul Natl Univ Childrens Hosp, Dept Pediat,Coll Med, Seoul, South Korea

[13] Soonchunhyang Univ, Dept Internal Med, Div Hematol Oncol, Seoul Hosp, Seoul, South Korea

[14] Yonsei Univ, Severance Hosp, Dept Pediat Hematol Oncol, Seoul, South Korea

[15] Univ Ulsan, Asan Med Ctr, Dept Hematol, Coll Med, Seoul, South Korea

[16] Ajou Univ, Dept Hematol Oncol, Sch Med, Suwon, South Korea

[17] Univ Ulsan, Ulsan Univ Hosp, Dept Hematol & Oncol, Coll Med, Ulsan, South Korea

[18] Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea

[19] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Sch Med, Hwasun, Jeonranamdo, South Korea

[20] Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Div Hematol Oncol,Coll Med, Busan, South Korea

来源：

BLOOD CANCER JOURNAL | 2023年 / 13卷 / 01期

关键词：

ALLOGENEIC TRANSPLANTATION; REMISSIONS; THERAPY; RELAPSE; COHORT;

D O I：

10.1038/s41408-023-00868-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 patients who underwent transplantation for T-cell lymphomas from 2010 to 2020. In total, 317 patients underwent up-front SCT as consolidation therapy. The 3-year progression-free survival (PFS) and overall survival (OS) were 68.7% and 76.1%, respectively. Patients who underwent auto-SCT had significantly better OS (p = 0.026) than those who underwent allo-SCT; however, no statistical difference in PFS was found. Transplantation was used as a salvage therapy in 188 patients who had relapsed/refractory disease. Overall, 96 (51.1%) patients underwent auto-SCT and 92 (48.9%) patients underwent allo-SCT. Auto-SCT improved long-term survival in patients with complete remission (CR). Allo-SCT demonstrated better 3-year PFS in patients with partial remission and relapsed/refractory disease status. However, >50% of patients died within 1 year of allo-SCT. As a consolidative therapy, up-front auto-SCT demonstrated a survival benefit. Auto-SCT was also effective in patients who achieved CR after salvage therapy. If the disease persists or cannot be controlled, allo-SCT may be considered with reduced intensity conditioning.

引用

页数：8

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