Therapeutic targeting of the KIF18A motor protein in cancers with chromosomal instability

被引：0
|
作者：
Payton, Marc [1 ]
Hughes, Paul E. [1 ]
机构：
[1] Amgen Res, Thousand Oaks, CA 91320 USA
来源：
NATURE CANCER | 2024年 / 5卷 / 01期
关键词：
D O I：
10.1038/s43018-023-00700-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromosomal instability (CIN) (a hallmark of human cancer) is caused by persistent errors in chromosome segregation during mitosis. Pharmacological inhibition of the mitotic kinesin KIF18A selectively exploits a mitotic vulnerability for which cancer models with CIN are enriched, which leads to robust anti-cancer effects and durable tumor regression in mice.
引用
收藏
页码：10 / 11
页数：2
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