Therapeutic targeting of the KIF18A motor protein in cancers with chromosomal instability

被引：0

作者：

Payton, Marc ^{[1
]}

Hughes, Paul E. ^{[1
]}

机构：

[1] Amgen Res, Thousand Oaks, CA 91320 USA

来源：

NATURE CANCER | 2024年 / 5卷 / 01期

关键词：

D O I：

10.1038/s43018-023-00700-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal instability (CIN) (a hallmark of human cancer) is caused by persistent errors in chromosome segregation during mitosis. Pharmacological inhibition of the mitotic kinesin KIF18A selectively exploits a mitotic vulnerability for which cancer models with CIN are enriched, which leads to robust anti-cancer effects and durable tumor regression in mice.

引用

页码：10 / 11

页数：2

共 38 条

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Nature Cancer, 2024, 5 : 10 - 11
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