Mosunetuzumab Monotherapy Demonstrates Durable Efficacy With a Manageable Safety Profile in Patients With Relapsed/Refractory Follicular Lymphoma who Received ≥2 Prior Therapies: Updated Results From a Pivotal Phase II Study

被引:0
|
作者
Bartlett, Nancy L. [1 ]
Sehn, Laurie H. [2 ,3 ]
Matasar, Matthew [4 ]
Schuster, Stephen J. [5 ]
Assouline, Sarit [6 ]
Giri, Pratyush [7 ]
Kuruvilla, John [8 ]
Canales, Miguel [9 ]
Dietrich, Sascha [10 ]
Fay, Keith [11 ,12 ]
Ku, Matthew [13 ]
Nastoupil, Loretta [14 ]
Wei, Michael C. [15 ]
Yin, Shen [15 ]
To, Iris [15 ]
Huang, Huang [16 ]
Min, Juliana [17 ]
Bolen, Christopher R. [15 ]
Penuel, Elicia [15 ]
Budde, L. Elizabeth [18 ]
机构
[1] Washington Univ, Siteman Canc Ctr, Sch Med, St Louis, MO USA
[2] BC Canc Ctr Lymphoid Canc, Vancouver, BC, Canada
[3] Univ British Columbia, Vancouver, BC, Canada
[4] Mem Sloan Kettering Canc Ctr, New York, NY USA
[5] Univ Penn, Lymphoma Program, Abramson Canc Ctr, Philadelphia, PA USA
[6] McGill Univ, Jewish Gen Hosp, Montreal, PQ, Canada
[7] Royal Adelaide Hosp, Adelaide, SA, Australia
[8] Princess Margaret Canc Ctr, Toronto, ON, Canada
[9] Hosp Univ La Paz, Madrid, Spain
[10] Heidelberg Univ, Heidelberg, Germany
[11] St Vincents Hosp, Sydney, NSW, Australia
[12] Royal North Shore Hosp, Sydney, NSW, Australia
[13] Univ Melbourne, St Vincents Hosp, Melbourne, Australia
[14] MD Anderson Canc Ctr, Houston, TX USA
[15] Genentech Inc, San Francisco, CA USA
[16] Hoffmann La Roche Ltd, Mississauga, ON, Canada
[17] Roche Prod Ltd, Welwyn Garden City, Herts, England
[18] City Hope Natl Med Ctr, Duarte, CA USA
来源
关键词
IBCL; mosunetuzumab; bispecific antibody; relapsed/refractory; follicular lymphoma; Phase II;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
IBCL-458
引用
收藏
页码:S453 / S453
页数:1
相关论文
共 50 条
  • [31] Umbralisib monotherapy demonstrates efficacy and safety in patients with relapsed/refractory marginal zone lymphoma: A multicenter, open-label, registration directed Phase II study
    Fowler, Nathan H.
    Samaniego, Felipe
    Jurczak, Wojciech
    Lech-Maranda, Ewa
    Ghosh, Nilanjan
    Anz, Bertrand
    Patten, Piers
    Reeves, James A.
    Leslie, Lori A.
    Smolewski, Piotr
    Chavez, Julio C.
    Ghia, Paolo
    Tarella, Corrado
    Burke, John M.
    Sharman, Jeff
    Kolibaba, Kathryn
    O'Connor, Owen A.
    Cheah, Chan Y.
    Miskin, Hari P.
    Sportelli, Peter
    Weiss, Michael S.
    Zinzani, Pier Luigi
    CANCER RESEARCH, 2019, 79 (13)
  • [32] RESULTS FROM A PHASE II STUDY INVESTIGATING THE EFFICACY AND SAFETY OF LENALIDOMIDE ORAL MONOTHERAPY IN RELAPSED OR REFRACTORY INDOLENT NOW HODGKIN'S LYMPHOMA
    Peter, H. W.
    Vose, J. M.
    Moore, T. D.
    Reeder, C. B.
    Cole, C. E.
    Justice, G.
    Kaplan, H. P.
    Voralia, M.
    Pietronigro, D.
    Takeshita, K.
    Ervin-Haynes, A.
    Zeldis, J. B.
    Witzig, T. E.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 107 - 107
  • [33] Efficacy and safety of nivolumab monotherapy in patients with metastatic urothelial cancer (mUC) who have received prior treatment: Results from the phase II CheckMate 275 study
    Galsky, M. D.
    Retz, M.
    Siefker-Radtke, A. O.
    Baron, A.
    Necchi, A.
    Bedke, J.
    Plimack, E. R.
    Vaena, D.
    Grimm, M-O.
    Bracarda, S.
    Arranz Arija, J.
    Pal, S. K.
    Ohyama, C.
    Saci, A.
    Lambert, A.
    Krishnan, S.
    Azrilevich, A.
    Sharma, P.
    ANNALS OF ONCOLOGY, 2016, 27
  • [34] SAR245409 Monotherapy In Relapsed/Refractory Follicular Lymphoma: Preliminary Results From The Phase II ARD12130 Study
    Brown, Jennifer R.
    Hamadani, Mehdi
    Arnason, Jon
    Karlin, Lionel
    Hayslip, John
    Wagner-Johnston, Nina
    Cartron, Guillaume
    Ribrag, Vincent
    de Guibert, Sophie
    Opat, Stephen
    Tilly, Herve
    Cannel, Paul
    Janssens, Ann
    Offner, Fritz
    Ganguly, Siddhartha
    Ailawadhi, Sikander
    Millenson, Michael
    Bron, Dominique
    Xu, Yi
    Ruiz-Soto, Rodrigo
    Kersten, Marie Jose
    BLOOD, 2013, 122 (21)
  • [35] Mosunetuzumab Plus Polatuzumab Vedotin Demonstrates a Favorable Safety Profile and Efficacy in Patients (Pts) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma ( LBCL): Primary Analysis of a Phase Ib/II Study
    Budde, L. Elizabeth
    Olszewski, Adam J.
    Assouline, Sarit
    Lossos, Izidore S.
    Diefenbach, Catherine
    Kamdar, Manali
    Ghosh, Nilanjan
    Modi, Dipenkumar
    Sabry, Waleed
    Naik, Seema
    Mehta, Amitkumar
    Nakhoda, Shazia K.
    Smith, Stephen D.
    Dorritie, Kathleen
    Jia, Ting
    Pham, Song
    Huw, Ling-Yuh
    Wu, Hao
    To, Iris
    Wei, Michael C.
    Chavez, Julio C.
    BLOOD, 2023, 142
  • [36] Phase 2 Study Evaluating the Efficacy and Safety of Parsaclisib in Patients with Relapsed or Refractory Follicular Lymphoma (CITADEL-203)
    Lynch, Ryan C.
    Paneesha, Shankara
    Avigdor, Abraham
    McKinney, Matthew S.
    Wahlin, Bjorn E.
    Hrom, John S.
    Belada, David
    Canales, Miguel
    Cunningham, David
    Devizzi, Liliana
    Morley, Nicholas
    Zheng, Fred
    DeMarini, Douglas J.
    Jiang, Wei
    Trneny, Marek
    BLOOD, 2020, 136
  • [37] Phase 2 Study Evaluating the Efficacy and Safety of Parsaclisib in Patients With Relapsed or Refractory Follicular Lymphoma (CITADEL-203)
    Lynch, Ryan C.
    Paneesha, Shankara
    Avigdor, Abraham
    McKinney, Matthew S.
    Wahlin, Bjorn E.
    Hrom, John S.
    Belada, David
    Canales, Miguel
    Cunningham, David
    Devizzi, Liliana
    Morley, Nicholas
    Zheng, Fred
    DeMarini, Douglas J.
    Jiang, Wei
    Trneny, Marek
    CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, 2021, 19 (01) : 11 - 12
  • [38] CELESTIMO: A phase III trial evaluating the efficacy and safety of mosunetuzumab plus lenalidomide versus rituximab plus lenalidomide in patients with relapsed or refractory follicular lymphoma who have received ≥ 1 line of systemic therapy.
    Nastoupil, Loretta J.
    Morschhauser, Franck
    Scholz, Christian W.
    Bishton, Mark
    Yoon, Sung-Soo
    Giri, Pratyush
    Wei, Michael C.
    Knapp, Andrea
    Li, Chi-Chung
    Bottos, Alessia
    Li, Haocheng
    Purev, Enkhtsetseg
    Bartlett, Nancy L.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [39] Efficacy and Safety of Parsaclisib in Patients with Relapsed or Refractory Follicular Lymphoma: Primary Analysis from a Phase 2 Study (CITADEL-203)
    Lynch, Ryan C.
    Avigdor, Abraham
    McKinney, Matthew S.
    Paneesha, Shankara
    Wahlin, Bjorn
    Hrom, John S.
    Cunningham, David
    Morley, Nicholas
    Canales, Miguel
    Bastos-Oreiro, Mariana
    Belada, David
    Devizzi, Liliana
    Zheng, Fred
    DeMarini, Douglas J.
    Jiang, Wei
    Trneny, Marek
    BLOOD, 2021, 138
  • [40] Glofitamab Plus Polatuzumab Vedotin Continues to Demonstrate Frequent and Durable Responses and Has a Manageable Safety Profile in Patients with=2L Relapsed/Refractory DLBCL, Including HGBCL, and in Patients with Prior CAR T-Cell Therapy: Updated Results from a Phase Ib/II Study
    Hutchings, Martin
    Avigdor, Abraham
    Sureda Balari, Anna Maria
    Jose Terol, Maria
    Bosch, Francesc
    Corradini, Paolo
    Larsen, Thomas S.
    Rueda Dominguez, Antonio
    Skarbnik, Alan
    Joergensen, Judit Meszaros
    Lavie, David
    Gurion, Ronit
    Zinzani, Pier Luigi
    Pinto, Antonio
    Cordoba, Raul
    Bottos, Alessia
    Li, Donghang
    Relf, James
    De L'Etang, Audrey Filezac
    Sellam, Gila
    Gritti, Giuseppe
    BLOOD, 2023, 142