3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer

被引:0
|
作者
Joy, Joash Dominic
Malacrida, Beatrice
Laforets, Florian
Kotantaki, Panoraia
Maniati, Eleni
Hopkins, Sarah
Garrobo-Calleja, Ianire
Gautrot, Julien
Balkwill, Frances
机构
关键词
D O I
10.1158/1538-7445.AM2023-4576
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4576
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Adjuvant radiation for patients (pts) with high-grade serous ovarian cancer (HGSC) and T-cell infiltration.
    Kumar, Aalok
    Gilks, Cyril Blake
    Clarke, Blaise
    Aquino-Parsons, Christina
    McAlpine, Jessica N.
    Lum, Julian J.
    Tinker, Anna
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [42] T-cell Receptor Repertoire Profiling in High Grade Serous Ovarian Cancer Using Next-generation Sequencing
    Lo, B.
    Smiley, S.
    Wright, N.
    Sekhon, H.
    Weberpals, J.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2018, 20 (06): : 1015 - 1015
  • [43] Distinct T cell receptor repertoire diversity of clinically defined high-grade serous ovarian cancer treatment subgroups
    Lee, Sanghoon
    Zhao, Li
    Little, Latasha D.
    Westin, Shannon N.
    Jazarei, Amir A.
    Fleming, Nicole D.
    Zhang, Jianhua
    Futreal, P. Andrew
    Sood, Anil K.
    ISCIENCE, 2021, 24 (02)
  • [44] Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer.
    Malacrida, Beatrice
    Delaine-Smith, Robin
    Nichols, Sam
    Maniati, Eleni
    Jones, Roanne L.
    Knight, Martin M.
    Pearce, Oliver M.
    Balkwill, Frances R.
    CANCER RESEARCH, 2021, 81 (13)
  • [45] Evaluation of CAR-T cells cytotoxic efficacy against 3D cell-based model of solid tumor
    Valiullina, A.
    Zmievskaya, E.
    Zhuravleva, M.
    Petukhov, A.
    Rizvanov, A.
    Bulatov, E.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021, 51 : 129 - 130
  • [46] Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model
    Dey, Madhuri
    Kim, Myoung Hwan
    Dogan, Mikail
    Nagamine, Momoka
    Kozhaya, Lina
    Celik, Nazmiye
    Unutmaz, Derya
    Ozbolat, Ibrahim T.
    ADVANCED FUNCTIONAL MATERIALS, 2022, 32 (52)
  • [47] Transcriptional Landscape of 3D vs. 2D Ovarian Cancer Cell Models
    Kerslake, Rachel
    Belay, Birhanu
    Panfilov, Suzana
    Hall, Marcia
    Kyrou, Ioannis
    Randeva, Harpal S. S.
    Hyttinen, Jari
    Karteris, Emmanouil
    Sisu, Cristina
    CANCERS, 2023, 15 (13)
  • [48] Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics
    Mikulak, Joanna
    Terzoli, Sara
    Marzano, Paolo
    Cazzetta, Valentina
    Martiniello, Giampaolo
    Piazza, Rocco
    Viano, Maria Estefania
    Vitobello, Domenico
    Portuesi, Rosalba
    Grizzi, Fabio
    Hegazi, Mohamed A. A. A.
    Fiamengo, Barbara
    Basso, Gianluca
    Parachini, Lara
    Mannarino, Laura
    D'Incalci, Maurizio
    Marchini, Sergio
    Mavilio, Domenico
    CELL DEATH & DISEASE, 2025, 16 (01):
  • [49] Circulating T-cell receptor diversity as predictive biomarker for PARP inhibitors maintenance therapy in high grade serous ovarian cancer
    Shu, Tong
    Zhou, Zhipeng
    Bai, Jing
    Xiao, Xiao
    Gao, Min
    Zhang, Nan
    Wang, Hongguo
    Xia, Xuefeng
    Gao, Yunong
    Zheng, Hong
    GYNECOLOGIC ONCOLOGY, 2023, 168 : 135 - 143
  • [50] Marked inter- and intra-patient heterogeneity of T cell infiltrates in primary high-grade serous ovarian cancer
    Cybulska, P.
    LaVigne, K.
    Walther, T.
    Vargas, H. A.
    Chi, D. S.
    Gardner, G. J.
    Sonoda, Y.
    Weigelt, B.
    Sala, E.
    Charen, A. E. Snyder
    GYNECOLOGIC ONCOLOGY, 2017, 145 : 122 - 122