Sudocetaxel Zendusortide (TH1902), a peptide-drug conjugate for the treatment of sortilin-positive (SORT1+) TNBC and Her2-positive breast cancers

被引：0
|
作者：
Charfi, Cyndia
Demeule, Michel
Currie, Jean-Christophe
Zgheib, Alain
Danalache, Bogdan Alexandru
Beliveau, Richard
Marsolais, Christian
Annabi, Borhane
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-4493
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4493
引用
收藏
页数：2
相关论文
共 44 条
  • [1] TH1902, a docetaxel peptide-drug conjugate, shows pre-clinical efficacy in several Sortilin-positive (SORT1+) cancers.
    Marsolais, Christian
    Currie, Jean-Christophe
    Demeule, Michel
    Charfi, Cyndia
    Larocque, Alain
    Zgheib, Alain
    Beliveau, Richard
    Annabi, Borhane
    CANCER RESEARCH, 2021, 81 (13)
  • [2] A novel Sortilin-targeted docetaxel peptide conjugate (TH1902), for the treatment of Sortilin-positive (SORT1+) triple-negative breast cancer
    Marsolais, Christian
    Charfi, Cyndia
    Demeule, Michel
    Currie, Jean-Christophe
    Larocque, Alain
    Zgheib, Alain
    Duquette, Natacha
    Beliveau, Richard
    Annabi, Borhane
    CANCER RESEARCH, 2020, 80 (16)
  • [3] TH1902, a new docetaxel-peptide conjugate for the treatment of sortilin-positive triple-negative breast cancer
    Demeule, Michel
    Charfi, Cyndia
    Currie, Jean-Christophe
    Larocque, Alain
    Zgheib, Alain
    Kozelko, Sophie
    Beliveau, Richard
    Marsolais, Christian
    Annabi, Borhane
    CANCER SCIENCE, 2021, 112 (10) : 4317 - 4334
  • [4] TH1901, a novel curcumin-peptide conjugate for the treatment of Sortilin-positive (SORT1+) cancer
    Annabi, Borhane
    Demeule, Michel
    Currie, Jean-Christophe
    Larocque, Alain
    Zgheib, Alain
    Marsolais, Christian
    Beliveau, Richard
    CANCER RESEARCH, 2020, 80 (16)
  • [5] The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers
    Currie, Jean-Christophe
    Demeule, Michel
    Charfi, Cyndia
    Zgheib, Alain
    Larocque, Alain
    Danalache, Bogdan Alexandru
    Ouanouki, Amira
    Beliveau, Richard
    Marsolais, Christian
    Annabi, Borhane
    CANCERS, 2022, 14 (08)
  • [6] Long-term efficacy, safety and PK data of TH1902 (sudocetaxel zendusortide) in solid tumors: A novel SORT1-targeting peptide-drug-conjugate (PDC)
    Winer, Ira Seth
    Barve, Minal A.
    Shah, Satish
    Sharma, Manish
    Marsolais, Christian
    Demeule, Michel
    Daigle, Kathya
    Douglas, Lynn Marie
    Meric-Bernstam, Funda
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [7] A Novel Homodimer Peptide-Drug Conjugate Improves the Efficacy of HER2-Positive Breast Cancer Therapy
    Liu, Shurong
    Tian, Ye
    Jiang, Sujun
    Wang, Zihua
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (05)
  • [8] The TH1902 Docetaxel Peptide-Drug Conjugate Inhibits Xenografts Growth of Human SORT1-Positive Ovarian and Triple-Negative Breast Cancer Stem-like Cells
    Demeule, Michel
    Charfi, Cyndia
    Currie, Jean-Christophe
    Zgheib, Alain
    Danalache, Bogdan Alexandru
    Beliveau, Richard
    Marsolais, Christian
    Annabi, Borhane
    PHARMACEUTICS, 2022, 14 (09)
  • [9] Anti-cancer efficacy of TH1902, a SORT1 docetaxel peptide-drug conjugate, against ovarian and endometrial cancers xenografts alone or in combination with carboplatin
    Marsolais, Christian
    Demeule, Michel
    Charfi, Cyndia
    Currie, Jean-Christophe
    Larocque, Alain
    Zgheib, Alain
    Beliveau, Richard
    Annabi, Borhane
    CANCER RESEARCH, 2022, 82 (12)
  • [10] Sudocetaxel zendusortide (TH1902), a novel sortilin-receptor (SORT1)-targeting peptide-drug-conjugate (PDC) in patients (pts) with advanced solid tumors: Results from part 1 (dose-escalation) of a phase 1, open-label study.
    Meric-Bernstam, Funda
    Shah, Satish
    Sharma, Manish
    Metcalfe, Annick
    Roy, Guylaine
    Douglas, Lynn Marie
    Marsolais, Christian
    Winer, Ira Seth
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
12345