Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

被引：34

作者：

Li, Qi ^{[1
]}

Wang, Zhen ^{[1
]}

Dong, Vy M. ^{[2
]}

Yang, Xiao-Hui ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Chem & Chem Engn, Minist Ind & Informat Technol, Adv Res Inst Multidisciplinary Sci,Key Lab Med Mol, Beijing 100081, Peoples R China

[2] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2023年

基金：

北京市自然科学基金; 美国国家卫生研究院; 中国国家自然科学基金; 美国国家科学基金会;

关键词：

C-H FUNCTIONALIZATION; ASYMMETRIC HYDROFUNCTIONALIZATION; ALLYLIC ALKYLATION; OXIDATIVE ADDITION; METAL; ALLENES; ALCOHOLS; ETHERS; ACTIVATION; PALLADIUM;

D O I：

10.1021/jacs.2c12779

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio-and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

引用

页码：3909 / 3914

页数：6

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