A protein bridge to death between the ER and mitochondria

被引：1

作者：

Lin, Jialing ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Biochem & Mol Biol, Hlth Sci Ctr, Oklahoma City, OK 73019 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2023年 / 299卷 / 04期

关键词：

RETICULUM; BCL-2;

D O I：

10.1016/j.jbc.2023.104581

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Commitment to apoptotic cell death occurs at the mito-chondria and is regulated by BCL-2 family proteins localized to this organelle. However, BIK, a resident protein of the endo-plasmic reticulum, inhibits mitochondrial BCL-2 proteins to promote apoptosis. In a recent paper in the JBC, Osterlund et al. investigated this conundrum. Surprisingly, they discov-ered that these endoplasmic reticulum and mitochondrial proteins moved toward each other and met at the contact site between the two organelles, thereby forming a 'bridge to death'.

引用

页数：3

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