Determining the role of peroxidation of subcellular lipid membranes in ferroptosis

被引：2
|
作者：
von Krusenstiern, A. Nikolai [1 ]
Stockwell, Brent R. [1 ]
机构：
[1] Columbia Univ, New York, NY 10027 USA
来源：
NATURE CHEMICAL BIOLOGY | 2023年 / 19卷 / 06期
关键词：
D O I：
10.1038/s41589-022-01250-w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ferroptosis can be induced by lipid peroxidation in various subcellular membranes, including the endoplasmic reticulum (ER), mitochondria and lysosomes. By studying the subcellular distribution of ferroptosis-modulating fatty acids, we observed that the ER is a key initial site of peroxidation, followed by the plasma membrane, whereas other organelles are not as critical for ferroptosis.
引用
收藏
页码：674 / 675
页数：2
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