Longitudinal study of clinical and neurophysiological features in essential tremor

被引:19
|
作者
Angelini, Luca [1 ]
Paparella, Giulia [2 ]
De Biase, Alessandro [1 ]
Maraone, Annalisa [1 ]
Panfili, Matteo [1 ]
Berardelli, Isabella [3 ]
Cannavacciuolo, Antonio [2 ]
Di Vita, Antonella [1 ]
Margiotta, Roberta [1 ]
Fabbrini, Giovanni [1 ,2 ]
Berardelli, Alfredo [1 ,2 ]
Bologna, Matteo [1 ,2 ]
机构
[1] Sapienza Univ Rome, Dept Human Neurosci, Viale Univ 30, I-00185 Rome, Italy
[2] IRCCS Neuromed, Pozzilli, IS, Italy
[3] Sapienza Univ Rome, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy
关键词
essential tremor; kinematic; neurophysiology; tremor classification; MILD COGNITIVE IMPAIRMENT; ONSET ESSENTIAL TREMOR; REST TREMOR; PARKINSON; DECLINE; COHORT;
D O I
10.1111/ene.15650
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and purpose: Essential tremor (ET) is a common and heterogeneous disorder characterized by postural/kinetic tremor of the upper limbs and other body segments and by non--motor symptoms, including cognitive and psychiatric abnormalities. Only a limited number of longitudinal studies have comprehensively and simultaneously investigated motor and non--motor symptom progression in ET. Possible soft signs that configure the ET--plus diagnosis are also under--investigated in follow--up studies. We aimed to longitudinally investigate the progression of ET manifestations by means of clinical and neurophysiological evaluation. Methods: Thirty--seven ET patients underwent evaluation at baseline (T0) and at follow-up ( T1; mean interval +/- SD = 39.89 +/- 9.83 months). The assessment included the clinical and kinematic evaluation of tremor and voluntary movement execution, as well as the investigation of cognitive and psychiatric disorders. Results: A higher percentage of patients showed tremor in multiple body segments and rest tremor at T1 as compared to T0 (all p--values < 0.01). At T1, the kinematic analysis revealed reduced finger--tapping movement amplitude and velocity as compared to T0 (both p--values < 0.001). The prevalence of cognitive and psychiatric disorders did not change between T0 and T1. Female sex, absence of family history, and rest tremor at baseline were identified as predictive factors of worse disease progression. Conclusions: ET progression is characterized by the spread of tremor in multiple body segments and by the emergence of soft signs. We also identified possible predictors of disease worsening. The results contribute to a better understanding of ET classification and pathophysiology.
引用
收藏
页码:631 / 640
页数:10
相关论文
共 50 条
  • [31] LONGITUDINAL CLINICAL AND NEUROPHYSIOLOGICAL STUDY OF POLYNEUROPATHY IN JUVENILE DIABETES
    ZIDAR, J
    VODUSEK, DB
    BRUS, L
    ZDRAVSTVENI VESTNIK, 1979, 48 (11): : 645 - 648
  • [32] Spiral drawing features are similar between essential tremor and essential tremor plus
    Anandapadmanabhan, R.
    Vishnoi, A.
    Latorre, A.
    Thirugnanasambandam, N.
    Dipani, A.
    Biswas, D.
    Srivastava, A.
    Bhatia, K.
    Rajan, R.
    MOVEMENT DISORDERS, 2023, 38 : S423 - S424
  • [33] Conversion Rate of Essential Tremor to Essential Tremor-Parkinson's Disease: Data from a Prospective, Longitudinal Study
    Louis, Elan
    Berry, Diane
    Ghanem, Ali
    Cosentino, Stephanie
    NEUROLOGY, 2023, 100 (17)
  • [34] Clinical correlates of "pure" essential tremor: the TITAN study
    Erro, Roberto
    Lazzeri, Giulia
    Gigante, Angelo Fabio
    Pilotto, Andrea
    Magistrelli, Luca
    Bologna, Matteo
    Terranova, Carmen
    Olivola, Enrica
    Dallocchio, Carlo
    Moschella, Vincenzo
    Valentino, Francesca
    Di Biasio, Francesca
    Nicoletti, Alessandra
    De Micco, Rosa
    Brusa, Livia
    Sorrentino, Cristiano
    Matinella, Angela
    Bertino, Salvatore
    Paparella, Giulia
    Modugno, Nicola
    Contaldi, Elena
    Padovani, Alessandro
    Di Fonzo, Alessio
    Restaino, Marialuisa
    Barone, Paolo
    FRONTIERS IN NEUROLOGY, 2023, 14
  • [35] Clinical and genetic study of essential tremor in the Italian population
    G. Abbruzzese
    S. Pigullo
    E. Di Maria
    P. Martinelli
    P. Barone
    R. Marchese
    C. Scaglione
    A. Assini
    C. Lucetti
    A. Berardelli
    S. Calzetti
    E. Bellone
    F. Ajmar
    P. Mandich
    Neurological Sciences, 2001, 22 : 39 - 40
  • [36] Clinical and genetic study of essential tremor in the Italian population
    Abbruzzese, G
    Pigullo, S
    Di Maria, E
    Martinelli, P
    Barone, P
    Marchese, R
    Scaglione, C
    Assini, A
    Lucetti, C
    Berardelli, A
    Calzetti, S
    Bellone, E
    Ajmar, F
    Mandich, P
    NEUROLOGICAL SCIENCES, 2001, 22 (01) : 39 - 40
  • [37] Essential tremor and cognitive functioning: A clinical and imaging study
    Novellino, Fabiana
    Sacca, Valeria
    Chiriaco, Carmelina
    Salsone, Maria
    Nicoletti, Giuseppe
    Nistico, Rita
    Quattrone, Andrea
    Morelli, Maurizio
    Arabia, Gennarina
    Quattrone, Aldo
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2021, 429 : 337 - 337
  • [38] ANATOMICO-CLINICAL STUDY OF A CASE OF ESSENTIAL TREMOR
    LAPRESLE, J
    RONDOT, P
    SAID, G
    REVUE NEUROLOGIQUE, 1974, 130 (9-10) : 343 - 348
  • [39] Parkinsonian features in essential tremor patients
    Prado, R. P.
    Ferreira, L. C.
    Prado, A. G. P.
    MOVEMENT DISORDERS, 2010, 25 (07) : S533 - S534
  • [40] Essential tremor: Beyond the motor features
    Chandran, Vijay
    Pal, Pramod Kumar
    PARKINSONISM & RELATED DISORDERS, 2012, 18 (05) : 407 - 413