SGN-35C: A Novel CD30-Directed Antibody-Drug Conjugate for the Treatment of Lymphomas

被引：3
|
作者：
Hamblett, Kevin J. [1 ]
Cochran, Julia [1 ]
Snead, Katie [1 ]
Jin, Steven [1 ]
Yumul, Roma [1 ]
Simmons, Jessica [1 ]
Stone, Ivan [1 ]
Lyski, Ryan [1 ]
Schrum, Jason P. [1 ]
Lim, Andrea R. [1 ]
Clarke, Astrid [1 ]
机构：
[1] Seagen Inc, Bothell, WA USA
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-182400
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：2
相关论文
共 50 条
  • [31] BRENTUXIMAB VEDOTIN Anti-CD30 Antibody-Drug Conjugate Oncolytic
    Copeland, A.
    Younes, A.
    DRUGS OF THE FUTURE, 2010, 35 (10) : 797 - 801
  • [32] Specific tumor targeting and potent bystander killing with SGN-35, an anti-CD30 antibody drug conjugate.
    Okeley, Nicole M.
    Alley, Stephen C.
    Cerveny, Charles G.
    Andreyka, Jamie
    Sanderson, Russell J.
    Anderson, Martha
    Benjamin, Dennis R.
    Law, Che-Leung
    Sievers, Eric
    Ihle, Nathan C.
    BLOOD, 2006, 108 (11) : 72A - 72A
  • [33] SGN-CD352A: A novel humanized anti-CD352 antibody -drug conjugate for the treatment of multiple myeloma
    Lewis, Tim
    Olson, Devra J.
    Gordon, Kristine A.
    Sandal, Sharsti L.
    Miyamoto, Jamie
    VVestendorf, Lori
    Linares, Germein
    Leiske, Chris
    Kostner, Heather
    Stone, Ivan
    Anderson, Martha
    Nesterova, Albina
    Jonas, Mechthild
    Law, Che-Leung
    CANCER RESEARCH, 2016, 76
  • [34] Targeted ablation of human CD30 positive cells with an anti-CD30-MMAE antibody-drug conjugate (SGN-35) in vivo inhibits antigen-specific secondary immune responses
    Oflazoglu, Ezogelin
    Zeng, Weiping
    Klussman, Kerry
    McEarchern, Julie A.
    Law, Che-Leung
    Grewal, Iqbal S.
    Sievers, Eric L.
    Gerber, Hans-Peter
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [35] SGN-LIV1A: A Novel Antibody-Drug Conjugate Targeting LIV-1 for the Treatment of Metastatic Breast Cancer
    Sussman, Django
    Smith, Leia M.
    Anderson, Martha E.
    Duniho, Steve
    Hunter, Joshua H.
    Kostner, Heather
    Miyamoto, Jamie B.
    Nesterova, Albina
    Westendorf, Lori
    Van Epps, Heather A.
    Whiting, Nancy
    Benjamin, Dennis R.
    MOLECULAR CANCER THERAPEUTICS, 2014, 13 (12) : 2991 - 3000
  • [36] SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML
    Sutherland, May S. Kung
    Walter, Roland B.
    Jeffrey, Scott C.
    Burke, Patrick J.
    Yu, Changpu
    Kostner, Heather
    Stone, Ivan
    Ryan, Maureen C.
    Sussman, Django
    Lyon, Robert P.
    Zeng, Weiping
    Harrington, Kimberly H.
    Klussman, Kerry
    Westendorf, Lori
    Meyer, David
    Bernstein, Irwin D.
    Senter, Peter D.
    Benjamin, Dennis R.
    Drachman, Jonathan G.
    McEarchern, Julie A.
    BLOOD, 2013, 122 (08) : 1455 - 1463
  • [37] SGN-CD33A: A Novel CD33-Directed Antibody-Drug Conjugate, Utilizing Pyrrolobenzodiazepine Dimers, Demonstrates Preclinical Antitumor Activity Against Multi-Drug Resistant Human AML
    Sutherland, May S. K.
    Walter, Roland B.
    Jeffrey, Scott C.
    Burke, Patrick J.
    Yu, Changpu
    Harrington, Kimberly H.
    Stone, Ivan
    Ryan, Maureen C.
    Sussman, Django
    Zeng, Weiping
    Benjamin, Dennis R.
    Bernstein, Irwin D.
    Senter, Peter D.
    Drachman, Jonathan G.
    McEarchern, Julie A.
    BLOOD, 2012, 120 (21)
  • [38] A novel antibody-drug conjugate, SGN-35 (anti-CD30-auristatin), induces objective responses in patients with relapsed or refractory Hodgkin lymphoma: preliminary results of a phase I tolerability study
    Younes, A.
    Forero-Torres, A.
    Bartlett, N.
    Leonard, J. P.
    Rege, B.
    Kennedy, D. A.
    Lorenz, J.
    Sievers, E. L.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 64 - 64
  • [39] PERSISTENCE OF CD30 EXPRESSION IN CD30-POSITIVE LYMPHOMAS FOLLOWING TREATMENT WITH BRENTUXIMAB VEDOTIN (SGN-35)
    Chen, W.
    Nathwani, N.
    Forman, S.
    Popplewell, L.
    Krishnan, A.
    Gomez, C.
    Karanes, C.
    Smith, E.
    Farol, L.
    Thomas, S.
    Kim, Y.
    HAEMATOLOGICA, 2012, 97 : 81 - 82
  • [40] A novel antibody-drug conjugate targeting SAIL for the treatment of hematologic malignancies
    Kim, S. Y.
    Theunissen, J-W
    Balibalos, J.
    Liao-Chan, S.
    Babcock, M. C.
    Wong, T.
    Cairns, B.
    Gonzalez, D.
    van der Horst, E. H.
    Perez, M.
    Levashova, Z.
    Chinn, L.
    D'Alessio, J. A.
    Flory, M.
    Bermudez, A.
    Jackson, D. Y.
    Ha, E.
    Monteon, J.
    Bruhns, M. F.
    Chen, G.
    Migone, T-S
    BLOOD CANCER JOURNAL, 2015, 5 : e316 - e316
12345