HALL: a comprehensive database for human aging and longevity studies

被引：8
|
作者：
Li, Hao [1 ,2 ,8 ]
Wu, Song [2 ,3 ,4 ,8 ]
Li, Jiaming [1 ,2 ,8 ]
Xiong, Zhuang [12 ]
Yang, Kuan [1 ,2 ,8 ,9 ]
Ye, Weidong [6 ,17 ]
Ren, Jie [1 ,2 ,8 ,9 ,11 ]
Wang, Qiaoran [1 ,2 ,8 ]
Xiong, Muzhao [1 ,2 ,8 ]
Zheng, Zikai [1 ,2 ,8 ]
Zhang, Shuo [1 ,2 ,8 ]
Han, Zichu [1 ,2 ,8 ]
Yang, Peng [1 ,2 ,8 ]
Jiang, Beier [6 ]
Ping, Jiale [1 ,2 ,8 ]
Zuo, Yuesheng [1 ,2 ,8 ]
Lu, Xiaoyong [1 ,2 ,8 ]
Zhai, Qiaocheng [6 ]
Yan, Haoteng [13 ,14 ,15 ]
Wang, Si [13 ,14 ,15 ,16 ]
Ma, Shuai [5 ,8 ,11 ,16 ]
Zhang, Bing [1 ,2 ]
Ye, Jinlin [6 ]
Qu, Jing [7 ,8 ,10 ,11 ,16 ]
Yang, Yun-Gui [1 ,2 ,8 ,9 ]
Zhang, Feng [17 ]
Liu, Guang-Hui [5 ,8 ,10 ,11 ,13 ,14 ,15 ,16 ]
Bao, Yiming [2 ,3 ,4 ,8 ]
Zhang, Weiqi [1 ,2 ,8 ,9 ,11 ,16 ]
机构：
[1] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China
[2] China Natl Ctr Bioinformat, Beijing 100101, Peoples R China
[3] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China
[4] Chinese Acad Sci, Beijing Inst Genom, Natl Genom Data Ctr, Beijing 100101, Peoples R China
[5] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China
[6] Wenzhou Med Univ, Quzhou Affiliated Hosp, Dept Vasc Surg, Beijing 100101, Peoples R China
[7] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China
[8] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[9] Univ Chinese Acad Sci, Sino Danish Coll, Beijing 101408, Peoples R China
[10] Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China
[11] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
[12] Fuzhou Univ, Interdiscip linary Inst Med Engn, Fuzhou 350002, Peoples R China
[13] Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Beijing 100053, Peoples R China
[14] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China
[15] Capital Med Univ, Xuanwu Hosp, Aging Translat Med Ctr, Beijing 100053, Peoples R China
[16] Aging Biomarker Consortium, Beijing 100101, Peoples R China
[17] Wenzhou Med Univ, Quzhou Affiliated Hosp, Joint Innovat Ctr Engn Med, Quzhou 324000, Peoples R China
来源：
NUCLEIC ACIDS RESEARCH | 2023年
关键词：
CENTENARIANS; OMICS; AGE;
D O I：
10.1093/nar/gkad880
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diverse individuals age at different rates and display variable susceptibilities to tissue aging, functional decline and aging-related diseases. Centenarians, exemplifying extreme longevity, serve as models for healthy aging. The field of human aging and longevity research is rapidly advancing, garnering significant attention and accumulating substantial data in recent years. Omics technologies, encompassing phenomics, genomics, transcriptomics, proteomics, metabolomics and microbiomics, have provided multidimensional insights and revolutionized cohort-based investigations into human aging and longevity. Accumulated data, covering diverse cells, tissues and cohorts across the lifespan necessitates the establishment of an open and integrated database. Addressing this, we established the Human Aging and Longevity Landscape (HALL), a comprehensive multi-omics repository encompassing a diverse spectrum of human cohorts, spanning from young adults to centenarians. The core objective of HALL is to foster healthy aging by offering an extensive repository of information on biomarkers that gauge the trajectory of human aging. Moreover, the database facilitates the development of diagnostic tools for aging-related conditions and empowers targeted interventions to enhance longevity. HALL is publicly available at https://ngdc.cncb.ac.cn/hall/index. Graphical Abstract
引用
收藏
页码：D909 / D918
页数：10
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