Pharmacological Modulation of Hsp70 to Selectively Remove Misfolded Neuronal Nitric Oxide Synthase

被引：0
|
作者：
Garcia, Anthony [1 ]
Xu, Emily [2 ]
Lau, Miranda [2 ]
Alt, Andrew [2 ]
Lieberman, Andrew [2 ]
Osawa, Yoichi [2 ]
机构：
[1] Univ Michigan, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Med Sch, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | 2023年 / 385卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1124/jpet.122.235890
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
332
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination
    Peng, Hwei-Ming
    Morishima, Yoshihiro
    Pratt, William B.
    Osawa, Yoichi
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (02) : 1556 - 1565
  • [2] High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase
    Garcia, Anthony M.
    Davis, Amanda K.
    Martinez-Ramos, Cristian
    Morishima, Yoshihiro
    Lau, Miranda
    Xu, Emily
    Sunil, Arya
    Zhang, Haoming
    Alt, Andrew
    Lieberman, Andrew P.
    Osawa, Yoichi
    MOLECULAR PHARMACOLOGY, 2025, 107 (02)
  • [3] Hsp70/nitric oxide relationship in apoptotic modulation during obstructive nephropathy
    Walter Manucha
    Patricia Vallés
    Cell Stress and Chaperones, 2008, 13 : 413 - 420
  • [4] Hsp70/nitric oxide relationship in apoptotic modulation during obstructive nephropathy
    Manucha, Walter
    Valles, Patricia
    CELL STRESS & CHAPERONES, 2008, 13 (04): : 413 - 420
  • [5] Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase
    Davis, Amanda K.
    McMyn, Natalie F.
    Lau, Miranda
    Morishima, Yoshihiro
    Osawa, Yoichi
    MOLECULAR PHARMACOLOGY, 2020, 98 (03) : 243 - 249
  • [6] Redox modulation of HSP 70 expression as a regulatory switch for inducible nitric oxide synthase
    Eiserich, JP
    Bamberg, TV
    Chumley, PH
    Corbacho, AM
    Clapp, C
    Lang, JD
    Freeman, BA
    FREE RADICAL BIOLOGY AND MEDICINE, 1999, 27 : S75 - S75
  • [7] PHARMACOLOGICAL MODULATION OF HSP70 IN CELLULAR MODELS OF HUNTINGTON'S DISEASE
    Reis, Sara D.
    Almeida, Liliana M.
    Pinho, Brigida R.
    Oliveira, Jorge M. A.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2018, 89 : A7 - A7
  • [8] Pharmacological Targeting of the Hsp70 Chaperone
    Patury, Srikanth
    Miyata, Yoshinari
    Gestwicki, Jason E.
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2009, 9 (15) : 1337 - 1351
  • [9] Biophysical Folding Sensors for the Detection of Misfolded Proteins by Hsp70
    Karunnayake, Chamithi
    Page, Richard
    FASEB JOURNAL, 2020, 34
  • [10] Nitric oxide activates synthesis of heat shock proteins (HSP70)
    Malyshev, IY
    Manukhina, EB
    Malugin, AV
    Mikoyan, VD
    Kubrina, LN
    Vanin, AF
    BIOLOGY OF NITRIC OXIDE, PT 5, 1996, 10 : 108 - 108
12345