Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages

被引：7

作者：

D'Rozario, Joshua ^{[1
,2
,3
,4
]}

Knoblich, Konstantin ^{[1
,2
,4
]}

Luetge, Mechthild ^{[5
]}

Shibayama, Christian Perez ^{[5
]}

Cheng, Hung-Wei ^{[5
]}

Alexandre, Yannick O. ^{[6
]}

Roberts, David ^{[4
]}

Campos, Joana ^{[7
]}

Dutton, Emma E. ^{[4
]}

Suliman, Muath ^{[4
]}

Denton, Alice E. ^{[8
]}

Turley, Shannon J. ^{[9
]}

Boyd, Richard L. ^{[10
]}

Mueller, Scott N. ^{[6
]}

Ludewig, Burkhard ^{[5
]}

Heng, Tracy S. P. ^{[3
,11
]}

Fletcher, Anne L. ^{[1
,2
,4
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Australia

[2] Monash Univ, Monash Biomed Discovery Inst, Clayton, Australia

[3] Monash Univ, Monash Biomed Discovery Inst, Dept Anat & Dev Biol, Clayton, Australia

[4] Univ Birmingham, Inst Immunol & Immunotherapy, Birmingham, England

[5] Kantonsspital St Gallen, Inst Immunobiol, St Gallen, Switzerland

[6] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, VIC, Australia

[7] Univ Birmingham, Inst Inflammat & Ageing, Birmingham, England

[8] Imperial Coll London, Dept Immunol & Inflammat, London, England

[9] Genentech Inc, Dept Canc Immunol, South San Francisco, CA USA

[10] Carther Pty Ltd, Hudson Inst Med Res, Clayton, Australia

[11] Monash Univ, ARC Training Ctr Cell & Tissue Engn Technol, Clayton, Australia

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2023年 / 53卷 / 09期

基金：

澳大利亚国家健康与医学研究理事会; 英国惠康基金; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

CSF1; Fibroblastic reticular cells; Human lymph nodes; Lymph node stromal cells; Macrophages; SUBCAPSULAR SINUS MACROPHAGES; STIMULATING FACTOR-I; DENDRITIC CELLS; ACTIVATION; MONOCYTES; ANTIGEN; TISSUE; HOMEOSTASIS; INFECTION; FOLLICLE;

D O I：

10.1002/eji.202250355

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis, but key factors controlling this niche are undefined. Here, we show that fibroblastic reticular cells (FRCs) are an essential component of the LN macrophage niche. Genetic ablation of FRCs caused rapid loss of macrophages and monocytes from LNs across two in vivo models. Macrophages co-localized with FRCs in human LNs, and murine single-cell RNA-sequencing revealed that FRC subsets broadly expressed master macrophage regulator CSF1. Functional assays containing purified FRCs and monocytes showed that CSF1R signaling was sufficient to support macrophage development. These effects were conserved between mouse and human systems. These data indicate an important role for FRCs in maintaining the LN parenchymal macrophage niche.

引用

页数：14

共 50 条

[41] The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
Jillian L Astarita
Viviana Cremasco
Jianxin Fu
Max C Darnell
James R Peck
Janice M Nieves-Bonilla
Kai Song
Yuji Kondo
Matthew C Woodruff
Alvin Gogineni
Lucas Onder
Burkhard Ludewig
Robby M Weimer
Michael C Carroll
David J Mooney
Lijun Xia
Shannon J Turley
Nature Immunology, 2015, 16 : 75 - 84
[42] The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
Astarita, Jillian L.
Cremasco, Viviana
Fu, Jianxin
Darnell, Max C.
Peck, James R.
Nieves-Bonilla, Janice M.
Song, Kai
Kondo, Yuji
Woodruff, Matthew C.
Gogineni, Alvin
Onder, Lucas
Ludewig, Burkhard
Weimer, Robby M.
Carroll, Michael C.
Mooney, David J.
Xia, Lijun
Turley, Shannon J.
NATURE IMMUNOLOGY, 2015, 16 (01) : 75 - +
[43] Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
Allan, Rhys S.
Waithman, Jason
Bedoui, Sammy
Jones, Claerwen M.
Villadangos, Jose A.
Zhan, Yifan
Lew, Andrew M.
Shortman, Ken
Heath, William R.
Carbone, Francis R.
IMMUNITY, 2006, 25 (01) : 153 - 162
[44] Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes
Gonzalez Badillo, Freddy
Zisi Tegou, Flavia
Masina, Riccardo
Wright, Shane
Scully, Mackenzie
Harwell, Laura
Lupp, Michael
Postigo-Fernandez, Jorge
Creusot, Remi J.
Tomei, Alice A.
CELLULAR AND MOLECULAR BIOENGINEERING, 2020, 13 (05) : 419 - 434
[45] Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes
Freddy Gonzalez Badillo
Flavia Zisi Tegou
Riccardo Masina
Shane Wright
Mackenzie Scully
Laura Harwell
Michael Lupp
Jorge Postigo-Fernandez
Remi J. Creusot
Alice A. Tomei
Cellular and Molecular Bioengineering, 2020, 13 : 419 - 434
[46] Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node
van Pul, Kim M.
Vuylsteke, Ronald J. C. L. M.
van de Ven, Rieneke
te Velde, Elisabeth A.
Rutgers, Emiel J. Th
van den Tol, Petrousjka M.
Stockmann, Hein B. A. C.
de Gruijl, Tanja D.
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
[47] Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
Link, Alexander
Vogt, Tobias K.
Favre, Stephanie
Britschgi, Mirjam R.
Acha-Orbea, Hans
Hinz, Boris
Cyster, Jason G.
Luther, Sanjiv A.
NATURE IMMUNOLOGY, 2007, 8 (11) : 1255 - 1265
[48] Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
María Casanova-Acebes
Erica Dalla
Andrew M. Leader
Jessica LeBerichel
Jovan Nikolic
Blanca M. Morales
Markus Brown
Christie Chang
Leanna Troncoso
Steven T. Chen
Ana Sastre-Perona
Matthew D. Park
Alexandra Tabachnikova
Maxime Dhainaut
Pauline Hamon
Barbara Maier
Catherine M. Sawai
Esperanza Agulló-Pascual
Markus Schober
Brian D. Brown
Boris Reizis
Thomas Marron
Ephraim Kenigsberg
Christine Moussion
Philippe Benaroch
Julio A. Aguirre-Ghiso
Miriam Merad
Nature, 2021, 595 : 578 - 584
[49] Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
Casanova-Acebes, Maria
Dalla, Erica
Leader, Andrew M.
LeBerichel, Jessica
Nikolic, Jovan
Morales, Blanca M.
Brown, Markus
Chang, Christie
Troncoso, Leanna
Chen, Steven T.
Sastre-Perona, Ana
Park, Matthew D.
Tabachnikova, Alexandra
Dhainaut, Maxime
Hamon, Pauline
Maier, Barbara
Sawai, Catherine M.
Agullo-Pascual, Esperanza
Schober, Markus
Brown, Brian D.
Reizis, Boris
Marron, Thomas
Kenigsberg, Ephraim
Moussion, Christine
Benaroch, Philippe
Aguirre-Ghiso, Julio A.
Merad, Miriam
NATURE, 2021, 595 (7868) : 578 - +
[50] Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1
Castellanos, Carlos A.
Ren, Xin
Gonzalez, Steven Lomeli
Li, Hong Kun
Schroeder, Andrew W.
Liang, Hong-Erh
Laidlaw, Brian J.
Hu, Donglei
Mak, Angel C. Y.
Eng, Celeste
Rodriguez-Santana, Jose R.
LeNoir, Michael
Yan, Qi
Celedon, Juan C.
Burchard, Esteban G.
Zamvil, Scott S.
Ishido, Satoshi
Locksley, Richard M.
Cyster, Jason G.
Huang, Xiaozhu
Shin, Jeoung-Sook
SCIENCE IMMUNOLOGY, 2021, 6 (64)

← 1 2 3 4 5 →