Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features

被引:9
|
作者
Spadaccini, Marco [1 ,2 ]
Bellocchi, Maria Cristina Conti [3 ]
Mangiavillano, Benedetto [4 ]
Fantin, Alberto [5 ]
Rahal, Daoud [6 ]
Manfrin, Erminia [3 ]
Gavazzi, Francesca [7 ]
Bozzarelli, Silvia [8 ]
Crino, Stefano Francesco [3 ]
Terrin, Maria [1 ,2 ]
Di Leo, Milena [9 ]
Bonifacio, Cristiana [10 ]
Facciorusso, Antonio [11 ]
Realdon, Stefano [5 ]
Cristofori, Chiara [5 ]
Auriemma, Francesco [4 ]
Fugazza, Alessandro [1 ]
Frulloni, Luca [3 ]
Hassan, Cesare [1 ,2 ]
Repici, Alessandro [1 ,2 ]
Carrara, Silvia [1 ]
机构
[1] IRCCS Humanitas Res Hosp, Dept Gastroenterol, Endoscop Unit, Via Manzoni 56, I-20089 Milan, Italy
[2] Humanitas Univ, Dept Biomed Sci, Via Manzoni 113, I-20089 Milan, Italy
[3] GB Rossi Univ Hosp, Pancreas Inst, Gastroenterol & Digest Endoscopy Unit, I-37134 Verona, Italy
[4] Humanitas Mater Domini, Div Gastroenterol, Digest Endoscopy Unit, I-21053 Castellanza, Italy
[5] Ist Oncol Veneto IOV IRCCS, Gastroenterol Unit, I-35128 Padua, Italy
[6] IRCCS Humanitas Res Hosp, Dept Pathol, Via Manzoni 56, I-20089 Milan, Italy
[7] IRCCS Humanitas Res Hosp, Pancreat Surg Unit, Via Manzoni 56, I-20089 Milan, Italy
[8] IRCCS Humanitas Res Hosp, Humanitas Canc Ctr, Med Oncol & Hematol Unit, Via Manzoni 56, I-20089 Milan, Italy
[9] San Paolo Hosp, Div Gastroenterol, Digest Endoscopy Unit, I-20090 Milan, Italy
[10] IRCCS Humanitas Res Hosp, Dept Radiol, Via Manzoni 56, I-20089 Milan, Italy
[11] Univ Foggia, Dept Surg & Med Sci, Gastroenterol Unit, I-71122 Foggia, Italy
关键词
pancreas; cancer; oncology; surgery; metastasis; FINE-NEEDLE-ASPIRATION; EUS-GUIDED FNA; METASTATIC TUMORS; IMAGING FEATURES; MASSES;
D O I
10.3390/jcm12082829
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 2021. We described clinical and pathological features, therapeutic approach and treatment outcomes. EUS characteristics of the lesions and the tissue acquisition procedures (needle, passages, histology) were recorded. A total of 116 patients (males/females 69/47; mean age 66.7) with 236 histologically confirmed pancreatic metastases were included; kidney was the most common primary site. EUS was performed to confirm the diagnosis in 205 lesions which presented as predominantly solitary (59), hypoechoic (95) and hypervascular (60), with a heterogeneous (n = 54) pattern and well-defined borders (n = 52). EUS-guided tissue acquisition was performed in 94 patients with an overall accuracy of 97.9%. Histological evaluation was possible in 88.3% of patients, obtaining final diagnosis in all cases. When cytology alone was performed, the final diagnosis was obtained in 83.3% of cases. A total of 67 patients underwent chemo/radiation therapy, and surgery was attempted in 45 (38.8%) patients. Pancreatic metastases are a possible event in the natural history of solid tumors, even long after the diagnosis of the primary site. EUS-guided fine needle biopsy may be suggested to implement the differential diagnosis.
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页数:10
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