Antiviral Activity of Technologically Processed Antibodies to CD4 Receptor against Influenza Infection

被引：0
|
作者：
Petrova, N. V. [1 ,3 ]
Emelyanova, A. G. [1 ,3 ]
Tarasov, S. A. [1 ,3 ]
Glubokova, E. A. [2 ]
Kartashova, N. P. [2 ]
机构：
[1] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia
[2] II Mechnikov Res Inst Vaccines & Sera, Moscow, Russia
[3] LLC MATERIA MEDICA HOLDING, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 174卷 / 02期
关键词：
influenza A infection; technologically processed antibodies; CD4; receptor; Ergoferon; Raphamin; EFFICACY; OSELTAMIVIR; ERGOFERON; SAFETY;
D O I：
10.1007/s10517-023-05683-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The antiviral activity of technologically processed antibodies to CD4 receptor was evaluated a model of sublethal A/California/04/2009 (H1N1)pdm09-induced influenza infection in female BALB/c mice. The technologically processed antibodies increased animal survival rate by 50% in comparison with the placebo group (p < 0.05), which correlated with significant inhibition of virus replication in the lungs (p < 0.05). The reference drug Tamiflu increased mouse survival rate (by 47%), decreased the virus titer in the lungs, and prevented body weight loss (p < 0.05 in comparison with the placebo group by all parameters). The intrinsic protective activity of technologically processed antibodies to CD4 receptor was demonstrated, which manifested in a decrease in viral load in the lower respiratory tract and an increase in the survival rate.
引用
收藏
页码：250 / 253
页数：4
相关论文
共 50 条
  • [41] ANTIVIRAL ACTIVITY OF CHELATED COBALT AGAINST INFLUENZA VIRUS
    GROUPE, V
    ENGLE, CG
    GAFFNEY, PE
    [J]. JOURNAL OF BACTERIOLOGY, 1955, 70 (05) : 623 - 624
  • [42] Assessment of the antiviral activity of MxA against influenza A virus
    Steiner, Fiona
    Spirig, Stefan
    Crameri, Michel
    Moritz, Eva
    Pavlovic, Jovan
    [J]. CYTOKINE, 2017, 100 : 84 - 84
  • [43] Antiviral activity of Jinchai capsule against influenza virus
    Zhong, Juying
    Cui, Xiaolan
    Shi, Yingjie
    Gao, Yingjie
    Cao, Hongxin
    [J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2013, 33 (02) : 200 - 204
  • [44] Activity of a Novel Fullerene-based Antiviral Against Influenza Virus Infection In Vitro and In Vivo
    Zarubaev, Vladimir
    Anfimov, Pavel
    Shtro, Anna
    Rasnetsov, Lev
    Kiselev, Oleg
    [J]. ANTIVIRAL RESEARCH, 2010, 86 (01) : A50 - A51
  • [45] Tolerance induction with CD4 monoclonal antibodies
    Waldmann, H
    Bemelman, F
    Cobbold, S
    [J]. IMMUNOLOGICAL TOLERANCE, 1998, 215 : 146 - 152
  • [46] The Development of CD4 Binding Site Antibodies during HIV-1 Infection
    Lynch, Rebecca M.
    Tran, Lillian
    Louder, Mark K.
    Schmidt, Stephen D.
    Cohen, Myron
    DerSimonian, Rebecca
    Euler, Zelda
    Gray, Elin S.
    Karim, Salim Abdool
    Kirchherr, Jennifer
    Montefiori, David C.
    Sibeko, Sengeziwe
    Soderberg, Kelly
    Tomaras, Georgia
    Yang, Zhi-Yong
    Nabel, Gary J.
    Schuitemaker, Hanneke
    Morris, Lynn
    Haynes, Barton F.
    Mascola, John R.
    [J]. JOURNAL OF VIROLOGY, 2012, 86 (14) : 7588 - 7595
  • [47] THE CD4 RECEPTOR FOR THE AIDS VIRUS
    WEISS, RA
    CLAPHAM, PR
    MCCLURE, M
    MARSH, M
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1989, 17 (04) : 644 - 647
  • [48] Regulation of CD4 T cell derived IL-10 during influenza infection
    Fonseca, Nicolette M.
    Redpath, Stephen A.
    Seo, Jung Hee
    Perona-Wright, Georgia
    [J]. CYTOKINE, 2013, 63 (03) : 262 - 262
  • [49] The role of IFN-γ in CD4 T cell trafficking and protection in response to influenza infection
    Brown, DM
    Roman, E
    Sorrell, K
    Swain, SL
    [J]. FASEB JOURNAL, 2003, 17 (07): : C165 - C165
  • [50] Efficient presentation of influenza virus to CD4 T cells is limited to days 1-4 of infection
    Jelley-Gibbs, DM
    Swain, SL
    [J]. FASEB JOURNAL, 2003, 17 (07): : C168 - C168
12345