Pyroptosis: a new insight into intestinal inflammation and cancer

被引：8
|
作者：
Chao, Limin [1 ]
Zhang, Wenjing [1 ]
Feng, Yuchao [1 ]
Gao, Pei [1 ]
Ma, Jinyou [1 ]
机构：
[1] Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
pyroptosis; inflammasomes; intestinal inflammation; cancer; gut microbiota; intestinal mucosal barrier; NLRP3; INFLAMMASOME; ACTIVATION; COLITIS; CASPASE-1; GUT; TUMORIGENESIS; MACROPHAGES; HOMEOSTASIS; APOPTOSIS; TARGET;
D O I：
10.3389/fimmu.2024.1364911
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy. In recent years, the roles of pyroptosis and inflammasomes in intestinal inflammation and cancer have been continuously confirmed. This article reviews the latest progress in pyroptosis mechanisms, new discoveries of inflammasomes, mutual regulation between inflammasomes, and their applications in intestinal diseases. Additionally, potential synergistic treatment mechanisms of intestinal diseases with pyroptosis are summarized, and challenges and future directions are discussed, providing new ideas for pyroptosis therapy.
引用
收藏
页数：9
相关论文
共 50 条
  • [31] NEW INSIGHT ON RESOLUTION OF INFLAMMATION DURING PERITONITIS
    Chene, G.
    Guigne, C.
    Baillif, V.
    Dubourdeau, M.
    INFLAMMATION RESEARCH, 2010, 59 : S289 - S289
  • [32] NEW MODELS OF CHRONIC INTESTINAL INFLAMMATION
    BHAN, AK
    MIZOGUCHI, E
    MIZOGUCHI, A
    CURRENT OPINION IN GASTROENTEROLOGY, 1994, 10 (06) : 633 - 638
  • [33] Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells
    Jin Huang
    Pingsheng Fan
    Miao Liu
    Chengtao Weng
    Gaofei Fan
    Tengyue Zhang
    Xiaohong Duan
    Yang Wu
    Lili Tang
    Guohong Yang
    Yabei Liu
    BMC Pharmacology and Toxicology, 22
  • [34] Pyroptosis Provides New Strategies for the Treatment of Cancer
    Jia, Yuming
    Wang, Xin
    Deng, Yanli
    Li, Shengchao
    Xu, Xiaowu
    Qin, Yi
    Peng, Li
    JOURNAL OF CANCER, 2023, 14 (01): : 140 - 151
  • [35] The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection
    Zhou, Cheng-Bei
    Fang, Jing-Yuan
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2019, 1872 (01): : 1 - 10
  • [36] Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells
    Huang, Jin
    Fan, Pingsheng
    Liu, Miao
    Weng, Chengtao
    Fan, Gaofei
    Zhang, Tengyue
    Duan, Xiaohong
    Wu, Yang
    Tang, Lili
    Yang, Guohong
    Liu, Yabei
    BMC PHARMACOLOGY & TOXICOLOGY, 2021, 22 (01):
  • [37] Ellagic Acid Ameliorates Ovarian Cancer via Modification of Pyroptosis and Inflammation
    Sun, Yan
    Hu, Xin
    Wang, Ying
    IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2025, 24 (01) : 100 - 114
  • [38] Pyroptosis in development, inflammation and disease
    Pan, Yuhong
    Cai, Wenjun
    Huang, Juan
    Cheng, Anchun
    Wang, Mingshu
    Yin, Zhongqiong
    Jia, Renyong
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [39] Monocarboxylate Transporter 4 Triggered Cell Pyroptosis to Aggravate Intestinal Inflammation in Inflammatory Bowel Disease
    Wang, Yaodong
    Zhou, Xiaorong
    Zou, Kejian
    Chen, Guanhua
    Huang, Ling
    Yang, Fangying
    Pan, Wenxu
    Xu, Hongwei
    Xu, Zhaohui
    Chen, Huan
    Chen, Jiayu
    Gong, Sitang
    Zhou, Xuan
    Xu, Wanfu
    Zhao, Junhong
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [40] Pyroptosis in platelets: Thrombocytopenia and inflammation
    Su, Yang
    Zhang, Tiannan
    Qiao, Rui
    JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2023, 37 (04)
12345