Redox-Neutral Decarboxylative and Desulfonylative C(sp3) Trifluoromethylation: Method Development and Mechanistic Inquiry

被引：2
|
作者：
Seong, Chris M. [1 ]
Roberts, Courtney C. [1 ]
机构：
[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 89卷 / 22期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
MEDIATED TRIFLUOROMETHYLATION; RADICALS; FLUORINE; DISCOVERY; ALKENES; ALKYL;
D O I：
10.1021/acs.joc.3c00872
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Sodium triflinate (CF3SO2Na) isan inexpensivebench-stable radical CF3 source that is often activatedby external oxidants such as peroxides. However, despite the commercialaccessibility of CF3SO2Na, the salt has neverbeen applied to decarboxylative trifluoromethylation due to challengesin controlled cross-radical coupling. We report a redox-neutral approachto decarboxylative C(sp(3)) trifluoromethylation of carboxylicacid derivatives. Mechanistic inquiry is performed to address thelimitations in scope.
引用
收藏
页码：16114 / 16120
页数：7
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