A retrospective multicentric cohort study of checkpoint inhibitors-induced pruritus with focus on management

被引:1
|
作者
Papageorgiou, Chryssoula [1 ,7 ]
Lazaridou, Elizabeth [1 ]
Lallas, Konstantinos [2 ]
Papaioannou, Kyparissos [3 ]
Nikolaou, Vasiliki [4 ]
Mateeva, Valeria [5 ]
Efthymiadis, Konstantinos [2 ]
Koukoutzeli, Chrysanthi [2 ]
Loga, Konstantia [2 ]
Sogka, Eleni [2 ]
Karamitrousis, Evangelos [2 ]
Lazaridis, George [2 ]
Dionysopoulos, Dimitrios [2 ]
Lallas, Aimilios [6 ]
Kemanetzi, Christina [1 ]
Fotiadou, Christina [1 ]
Timotheadou, Eleni [2 ]
Apalla, Zoe [1 ]
机构
[1] Aristotle Univ Thessaloniki, Fac Hlth Sci, Med Sch, Dermatol Dept 2, Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Fac Hlth Sci, Sch Med,Dept Med Oncol, Thessaloniki, Greece
[3] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Thessaloniki, Greece
[4] Natl & Kapodistrian Univ Athens, A Sygros Hosp Skin & Venereal Dis, Fac Med, Dept Dermatol Venereol, Athens, Greece
[5] Med Univ Sofia, Med Fac, Dept Dermatol & Venereol, Sofia, Bulgaria
[6] Aristotle Univ Thessaloniki, Fac Hlth Sci, Med Sch, Dermatol Dept 1, Thessaloniki, Greece
[7] Aristotle Univ Thessaloniki, Dermatol Dept 2, 76 Agiou Pavlou, Thessaloniki 56429, Greece
关键词
immune checkpoint inhibitors; immunotherapy; narrow-band UVB (NBUVB); phototherapy; pruritus; VISUAL ANALOG SCALE; ADVERSE EVENTS; RATING-SCALE; NIVOLUMAB; IRRADIATION; ASSOCIATION; ITCH;
D O I
10.1111/phpp.12892
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
BackgroundLimited data on immune checkpoint inhibitor (ICI)-induced pruritus per se and efficacy of different therapeutic modalities in its management exist. ObjectiveTo study the quantitative and qualitative characteristics of ICI-induced pruritus per se and to assess the efficacy of the therapeutic modalities usually applied. MethodsWe retrospectively reviewed the records of 91 patients who were under treatment with ICIs for any kind of neoplasia and developed pruritus during treatment. ResultsTwenty out of 91 individuals (22.0%) with ICI-induced pruritus had pruritus as the only symptom, while 71/91 (78.0%) presented with pruritus coexisting with an additional cutaneous toxicity. Pruritus was treated with antihistamines (18/20, 90.0%) and/or topical regimens, as first-line choice. In resistant cases, as a second therapeutic intervention, narrow-band UVB (NBUVB), oral steroids and GABA analogs were added (70.0%). Statistical analysis revealed a significant difference in mean pruritus Numerical Rating Scale (NRS) scores between baseline and sequential visits. Moreover, subgroup analysis revealed a significant reduction in mean NRS scores in those treated with phototherapy. LimitationsRetrospective design, low number of patients and survivorship bias. ConclusionPruritus per se was present in a substantial portion of our cohort (22.0%). Our study confirms the efficacy of current treatment strategies and suggests NBUVB as a potential steroid-sparing therapeutic alternative.
引用
收藏
页码:506 / 511
页数:6
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