A Cyclobutanol Ring-Expansion Approach to Oxygenated Carbazoles: Total Synthesis of Glycoborine, Carbazomycin A and Carbazomycin B

被引：7

作者：

Natho, Philipp ^{[1
]}

Allen, Lewis A. T. ^{[1
]}

Parsons, Philip J. ^{[1
]}

机构：

[1] Imperial Coll London, Dept Chem, London W12 0BZ, England

来源：

SYNLETT | 2023年 / 34卷 / 08期

基金：

英国工程与自然科学研究理事会;

关键词：

total synthesis; ring expansion; cyclization; antifungal agents; rearrangement; ALKALOIDS CARBAZOMYCIN; ORGANIC-SYNTHESIS; AMINATION; IDENTIFICATION; ANTIBIOTICS; COMPLEXES; ROOTS; ROUTE;

D O I：

10.1055/s-0042-1751411

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The transition-metal-free total syntheses of the oxygenated carbazole natural products glycoborine, carbazomycin A and carbazomycin B are reported. The key step involves an NBS-mediated cyclobutanol ring expansion to 4-tetralones for the preparation of the tricyclic carbazole core.

引用

页码：937 / 942

页数：6

共 38 条

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