Platelet-lymphocyte ratio is a prognostic marker in small cell lung cancer-A systemic review and meta-analysis

被引:5
|
作者
Zhou, Hongbin [1 ]
Li, Jiuke [2 ]
Zhang, Yiting [3 ]
Chen, Zhewen [4 ]
Chen, Ying [4 ]
Ye, Sa [4 ]
机构
[1] Hangzhou Med Coll, Affiliated Peoples Hosp, Canc Ctr, Dept Pulm & Crit Care Med,Zhejiang Prov Peoples Ho, Hangzhou, Zhejiang, Peoples R China
[2] Hangzhou Aier Eye Hosp, Dept Ophthalmol, Hangzhou, Zhejiang, Peoples R China
[3] Xianju Peoples Hosp, Dept Pulm & Crit Care Med, Taizhou, Zhejiang, Peoples R China
[4] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Gen Practice Med,Dept Clin Nutr, Hangzhou, Zhejiang, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2023年 / 12卷
关键词
small cell lung cancer (SCLC); platelet-lymphocyte ratio (PLR); overall survival (OS); progression-free survival (PFS); prognosis; NOMOGRAMS PREDICT; SURVIVAL; INFLAMMATION; PLR;
D O I
10.3389/fonc.2022.1086742
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim: The aim of this study was to evaluate the relationship between platelet-lymphocyte ratio (PLR) and prognosis in small cell lung cancer (SCLC) patients. Method: A comprehensive search was carried out to collect related studies. Two independent investigators extracted the data of hazard ratio (HR) and 95% confidence interval (CI) for overall survival (OS) or progression-free survival (PFS). A random-effect model was applied to analyze the effect of different PLR levels on OS and PFS in SCLC patients. Moreover, subgroup analysis was conducted to seek out the source of heterogeneity. Results: A total of 26 articles containing 5,592 SCLC patients were included for this meta-analysis. SCLC patients with a high PLR level had a shorter OS compared with patients with a low PLR level, in both univariate (HR = 1.56, 95% CI 1.28-1.90, p < 0.0001) and multivariate (HR = 1.31, 95% CI 1.08-1.59, p = 0.007) models. SCLC patients with a high PLR level had a shorter PFS compared with patients with a low PLR level, in the univariate model (HR = 1.71, 95% CI 1.35-2.16, p < 0.0001), but not in the multivariate model (HR = 1.17, 95% CI 0.95-1.45, p = 0.14). Subgroup analysis showed that a high level of PLR shortened OS in some subgroups, including the Asian subgroup, the younger subgroup, the mixed-stage subgroup, the chemotherapy-dominant subgroup, the high-cutoff-point subgroup, and the retrospective subgroup. PLR level did not affect OS in other subgroups. Conclusion: PLR was a good predictor for prognosis of SCLC patients, especially in patients received chemotherapy dominant treatments and predicting OS.
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页数:12
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